5958-08-7

Basic information

• Product Name: 6-chloro -4-phenyl quinazoline-2-carboxylic acid
• Synonyms: 6-chloro -4-phenyl quinazoline-2-carboxylic acid
• CAS NO: 5958-08-7
• Molecular Formula: C₁₅H₉ClN₂O₂
• Molecular Weight: 284.69716
• Mol File: 5958-08-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-chloro -4-phenyl quinazoline-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro -4-phenyl quinazoline-2-carboxylic acid(5958-08-7)
• EPA Substance Registry System: 6-chloro -4-phenyl quinazoline-2-carboxylic acid(5958-08-7)

Safety Data

• Hazardous Substances Data: 5958-08-7(Hazardous Substances Data)

Usage

General Description

6-Chloro-4-phenyl quinazoline-2-carboxylic acid is a chemical compound with a molecular formula C15H9ClN2O2. It is a quinazoline derivative that contains a chlorine atom and a phenyl group attached to the quinazoline ring. 6-chloro -4-phenyl quinazoline-2-carboxylic acid has potential pharmaceutical applications and is being studied for its biological activities, including its potential as an anticancer agent. It is also being investigated for its potential in the treatment of various other diseases and conditions. Additionally, it has been studied for its role as a building block in the synthesis of other complex organic compounds.

Upstream product

• 88190-77-6 6-chloro-3,4-dihydro-4-phenylquinazoline-2-carboxylic acid 
• 153681-82-4 6-chloro-1,2-dihydro-4-phenylquinazoline-2-carboxylic acid 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 51483-21-7 6-chloro-4-phenylquinazoline-2-carbonitrile 
• 4797-43-7 6-chloro-4-phenylquinazolin-2-ol 
• 5185-54-6 2-chloro-4-phenyl-6-chloroquinazoline 

Downstream Products

• 62705-47-9 methyl 6-chloro-4-phenylquinazoline-2-carboxylate 
• 4015-28-5 6-chloro-4-phenylquinazoline 
• 1373887-32-1 N-sec-butyl-6-chloro-4-phenylquinazoline-2-carboxamide 
• 1373887-33-2 N-sec-butyl-6-chloro-N-methyl-4-phenylquinazoline-2-carboxamide 
• 1373887-35-4 6-chloro-N-isopropyl-N-methyl-4-phenylquinazoline-2-carboxamide 
• 1373887-36-5 6-chloro-N,N-dihexyl-4-phenylquinazoline-2-carboxamide 
• 1373887-37-6 (6-chloro-4-phenylquinazolin-2-yl)(pyrrolidin-1-yl)methanone 
• 1373887-38-7 (6-chloro-4-phenylquinazolin-2-yl)(piperidin-1-yl)methanone 
• 1373887-39-8 azepan-1-yl(6-chloro-4-phenylquinazolin-2-yl)methanone 
• 1373887-61-6 6-chloro-N-isobutyl-4-phenylquinazoline-2-carboxamide 
• 1581275-44-6 N-benzyl-6-chloro-N-ethyl-4-phenylquinazoline-2-carboxamide 
• 1581275-65-1 N-benzyl-6-chloro-4-phenylquinazoline-2-carboxamide 
• 21184-49-6 6-chloro-4-phenylquinazoline-2-carboxamide 
• 14271-32-0 6-chloro-N-methyl-4-phenylquinazoline-2-carboxamide 

Relevant articles and documents

4-ARYLQUINAZOLINE DERIVATIVES AS INHIBITORS OF METHIONINE ADENOSYLTRANSFERASE 2A

The invention relates to certain derivatives of 4-arylquinazoline formula (I) which are inhibitors of methionine adenosyltransferase 2A (MAT2A). The invention also relates to pharmaceutical compositions comprising such compounds and methods of treating diseases that can be treated by inhibition of MAT2A such as cancer, including cancers characterized by reduced or no activity of methylthioadenosine phosphorylase (MTAP).

Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein

A series of novel 4-phenylquinazoline-2-carboxamides (1-58) were designed as aza-isosters of PK11195, the well-known 18 kDa translocator protein (TSPO) reference ligand, and synthesized by means of a very simple and efficient procedure. A number of these derivatives bind to the TSPO with Ki values in the nanomolar/subnanomolar range, show selectivity toward the central benzodiazepine receptor (BzR) and exhibit structure-affinity relationships consistent with a previously published pharmacophore/topological model of ligand-TSPO interaction.