153805-70-0Relevant articles and documents
Synthesis, X-ray crystal structure and optical properties of novel 2-aryl-3-ethoxycarbonyl-4-phenylpyrido[1,2-a]benzimidazoles
Chen, Xia,Yang, He,Feng, Lei,Jia, Jiong,Wang, Jianwu,Ge, Yanqing
, p. 382 - 389,8 (2020/07/30)
A series of novel 2-aryl-3-ethoxycarbonyl-4-phenylpyrido[1,2-a] benzimidazole derivatives were synthesized by the tandem reaction of 2-benzoyl benzimidazole and (Z)-ethyl 4-bromo-3-arylbut-2-enoate in the presence of potassium carbonate. The compounds were characterized using IR, 1H-NMR, 13C-NMR, HRMS and the structure of 6f was further determined by X-ray crystallography. Both absorption and fluorescence spectra characteristics of the compounds were investigated in acetonitrile and dichloromethane. The results showed that the absorption maxima of the compounds varied from 220 to 284 nm, depending on the structure of 2-aryl group. The fluorescence results revealed that these compounds exhibited blue-green fluorescence (463-475 nm) in dilute solutions and showed acceptable fluorescence quantum yields (PL = 0.13-0.73) in dichloromethane. Copyright
Co-catalyzed reductive cyclization of azido and cyano substituted α,β-unsaturated esters with NaBH4: enantioselective synthesis of (R)-baclofen and (R)-rolipram
Paraskar, Abhimanyu S.,Sudalai, Arumugam
, p. 4907 - 4916 (2007/10/03)
Sodium borohydride in combination with a catalytic amount of CoCl2 has been found to be an excellent catalytic system in reductive cyclizations of suitably substituted azido and cyano groups of α,β-unsaturated esters to afford γ and δ-lactams in high yields. The process has been demonstrated for the enantioselective synthesis of (R)-baclofen, (R)-rolipram, and (R)-4-fluorophenylpiperidinone, a key intermediate for (-)-paroxetine.
