16251-41-5 Usage
Description
1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline, also known as Ro 5-4864, is a chemical compound belonging to the class of isoquinoline derivatives. It acts as a ligand for the peripheral-type benzodiazepine receptor (PBR) and has been studied for its potential pharmacological effects, including the treatment of anxiety, depression, and neurodegenerative diseases. Additionally, it has been investigated for its role in modulating the production of inflammatory cytokines and its potential anti-inflammatory properties.
Uses
Used in Pharmaceutical Applications:
1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline is used as a potential therapeutic agent for the treatment of anxiety, depression, and neurodegenerative diseases. Its interaction with the peripheral-type benzodiazepine receptor (PBR) makes it a promising candidate for these applications.
Used in Anti-Inflammatory Applications:
In the field of anti-inflammatory research, 1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline is used as a potential modulator of inflammatory cytokine production. Its investigation into this area aims to understand its potential anti-inflammatory properties and how it may contribute to the treatment of inflammation-related conditions.
Used in Neurodegenerative Disease Research:
1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline is used as a research compound in the study of neurodegenerative diseases. Its potential pharmacological effects on these conditions are of interest to scientists seeking new treatments and therapies for such diseases.
Further research is necessary to fully understand the pharmacological effects and potential therapeutic applications of 1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline.
Check Digit Verification of cas no
The CAS Registry Mumber 16251-41-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,2,5 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 16251-41:
(7*1)+(6*6)+(5*2)+(4*5)+(3*1)+(2*4)+(1*1)=85
85 % 10 = 5
So 16251-41-5 is a valid CAS Registry Number.
16251-41-5Relevant articles and documents
Novel total syntheses of oxoaporphine alkaloids enabled by mild Cu-catalyzed tandem oxidation/aromatization of 1-Bn-DHIQs
Zheng, Bo,Qu, Hui-Ya,Meng, Tian-Zhuo,Lu, Xia,Zheng, Jie,He, Yun-Gang,Fan, Qi-Qi,Shi, Xiao-Xin
, p. 28997 - 29007 (2018/08/29)
Novel total syntheses of oxoaporphine alkaloids such as liriodenine, dicentrinone, cassameridine, lysicamine, oxoglaucine and O-methylmoschatoline were developed. The key step of these total syntheses is Cu-catalyzed conversion of 1-benzyl-3,4-dihydro-isoquinolines (1-Bn-DHIQs) to 1-benzoyl-isoquinolines (1-Bz-IQs) via tandem oxidation/aromatization. This novel Cu-catalyzed conversion has been studied in detail, and was successfully used for constructing the 1-Bz-IQ core.
The SYNTHESIS OF ERYTHRO- AND THREO-N-METHYL 7-HYDROXY-1,2,9,10-TETRAMETHOXYAPORPHINE
Chackalamannil, Samuel,Dalton, D. R.
, p. 2029 - 2032 (2007/10/02)
The total synthesis of the title compounds is described.
