16285-97-5

Basic information

• Product Name: p-methoxybenzoate^(1-)
• Synonyms: p-methoxybenzoate^(1-)
• CAS NO: 16285-97-5
• Molecular Weight: 151.142
• Mol File: 16285-97-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: p-methoxybenzoate^(1-)(CAS DataBase Reference)
• NIST Chemistry Reference: p-methoxybenzoate^(1-)(16285-97-5)
• EPA Substance Registry System: p-methoxybenzoate^(1-)(16285-97-5)

Safety Data

• Hazardous Substances Data: 16285-97-5(Hazardous Substances Data)

Upstream product

• 156086-10-1 N-(2,4-dimethoxyphenyl)-4-methoxybenzamide 
• 100-07-2 4-methoxy-benzoyl chloride 
• 69838-98-8 1-(4-methoxybenzoyl)pyrrolidine 
• 123-11-5 4-methoxy-benzaldehyde 
• 168780-79-8 S-4-methoxybenzoyl coenzyme A 
• 873073-29-1 1-(4-methoxybenzoyl)-1-azetidin-2-one 
• 100-09-4 4-methoxybenzoic acid 
• 1568-31-6 2-(5-methoxy-1-(4-methoxybenzoyl)-2-methyl-1H-indol-3-yl)acetic acid 
• 701-53-1 p-methoxybenzoyl fluoride 
• 4181-97-9 phenyl 4-methoxybenzoate 

Downstream Products

• 591-50-4 iodobenzene 
• 104911-37-7 3,3-dimethylbutynyl p-methoxybenzoate 
• 104911-38-8 4-methylpentynyl p-methoxybenzoate 
• 40054-22-6 3-(4-methoxy-benzoyl)-3H-benzooxazol-2-one 
• 41520-80-3 C₂₀H₁₇O₆P 
• 100-09-4 4-methoxybenzoic acid 
• 94-30-4 ethyl 4-methoxybenzoate 

Relevant articles and documents

Enhanced reactivity of twisted amides inside a molecular cage

When an amide group is distorted from its planar conformation, the conjugation between the nitrogen lone pair and the π* orbital of the carbonyl is disrupted and the reactivity towards nucleophiles is enhanced. Although there are several reports on the synthesis of activated twisted amides, amide activation through mechanical twisting is much less common. Here, we report twisted amides that are stabilized through their inclusion in a self-assembled coordination cage. When secondary aromatic amides are included in a Td-symmetric cage, the cis-twisted conformation is favoured over the trans-planar one—as evidenced by single-crystal X-ray diffraction analysis—revealing that the amide can twist by up to 34°. As a consequence of this distortion, the hydrolysis of amides is significantly accelerated upon inclusion. [Figure not available: see fulltext.]

Unexpected resistance to base-catalyzed hydrolysis of nitrogen pyramidal amides based on the 7-azabicyclic[2.2.1]heptane scaffold

Non-planar amides are usually transitional structures, that are involved in amide bond rotation and inversion of the nitrogen atom, but some ground-minimum non-planar amides have been reported. Non-planar amides are generally sensitive to water or other n

Structure-activity analysis of base and enzyme-catalyzed 4-hydroxybenzoyl coenzyme A hydrolysis

In this study, the second-order rate constant k2 of base-catalyzed hydrolysis and the values of kcat, Km and kcat/Km of wild-type Pseudomonas sp. CBS3 4-hydroxybenzoyl coenzyme A (4-HBA-CoA) thioesterase-catalyzed hydrolysis of 4-HBA-CoA and its para-substituted analogs were measured. For the base-catalyzed hydrolysis, the plot of log k2 vs the σ value of the para-substituents was linear with a slope (ρ) of 1.5. In the case of the enzyme-catalyzed hydrolysis, the kcat/Km values measured for the para-substituted analogs defined substrate specificity. Asp32 was shown to play a key role in substrate recognition, and in particular, in the discrimination between the targeted substrate and other cellular benzoyl-CoA thioesters.