16307-30-5Relevant articles and documents
Huber,Dreiding
, p. 748 (1974)
Intramolecular One-Carbon Homologation of Unstrained Ketones via C-C Activation-Enabled 1,1-Insertion of Alkenes
Huang, Jiangkun,Zhang, Rui,Wu, Xiuli,Dong, Guangbin,Xia, Ying
, p. 2436 - 2440 (2022/04/07)
Here, we describe the development of a Rh-catalyzed intramolecular one-carbon homologation of unstrained aryl ketones through a formal 1,1-insertion process of olefins, enabled by temporary directing group (TDG)-aided C-C activation. The reaction provides a distinct approach to access various substituted 1-indanones. Computational mechanistic studies reveal that the formal 1,1-insertion is realized by a selective C(sp2)-C(sp3) activation and turnover limiting 2,1-insertion into the alkene, followed by a facile β-H elimination and reinsertion process.
Enantioselective Nickel-Catalyzed Reductive Aryl/Alkenyl-Cyano Cyclization Coupling to All-Carbon Quaternary Stereocenters
Chen, Zi-Hao,Sun, Rui-Ze,Yao, Fei,Hu, Xu-Dong,Xiang, Long-Xue,Cong, Hengjiang,Liu, Wen-Bo
supporting information, p. 4776 - 4782 (2022/03/27)
An enantioselective nickel-catalyzed intramolecular reductive cross-coupling of C(sp2) electrophiles and cyano groups is reported. Enantioenriched CN-containing all-carbon quaternary stereocenters are assembled by desymmetrizing cyclization of aryl/alkeny
