16369-21-4

Basic information

• Product Name: 2-(PROPYLAMINO)ETHANOL
• Synonyms: 2-(propylamino)-ethano;Ethanol, 2-(propylamino)-;N-PROPYLETHANOLAMINE;2-(PROPYLAMINO)ETHANOL;2-(PROPYLAMINO)ETHANOL, 99+%;N-PropylEthanolamine(N-Pea);Propylaminoethanol;N-PROPYLAMINOETHANOL
• CAS NO: 16369-21-4
• Molecular Formula: C₅H₁₃NO
• Molecular Weight: 103.16
• EINECS: 240-426-6
• Mol File: 16369-21-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 29.84°C (estimate)
• Boiling Point: 182 °C(lit.)
• Flash Point: 178 °F
• Appearance: /
• Density: 0.9 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.29mmHg at 25°C
• Refractive Index: n20/D 1.4415(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 14.81±0.10(Predicted)
• CAS DataBase Reference: 2-(PROPYLAMINO)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(PROPYLAMINO)ETHANOL(16369-21-4)
• EPA Substance Registry System: 2-(PROPYLAMINO)ETHANOL(16369-21-4)

Safety Data

• Hazard Codes: C
• Statements: 20/21/22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 3
• RTECS: KM2885000
• Hazardous Substances Data: 16369-21-4(Hazardous Substances Data)

Usage

General Description

2-(Propylamino)ethanol, also known as N-propylethanolamine, is an organic compound that falls under the class of chemical entities known as amino alcohols. Amino alcohols contain both amine and alcohol functional groups. This chemical is often used in the production of pharmaceuticals, agrochemicals, and other chemicals. It is known for its efficient chemical reactivity and compatibility with other substances. Despite its beneficial qualities, proper handling precautions should be taken as exposure to the chemical may pose hazard risks like skin, eye irritation, and potential harm if inhaled or ingested.

InChI:InChI=1/C5H13NO/c1-2-3-6-4-5-7/h6-7H,2-5H2,1H3

Upstream product

• 75-21-8 oxirane 
• 107-10-8 propylamine 
• 106-94-5 propyl bromide 
• 141-43-5 ethanolamine 
• 4755-77-5 Ethyl oxalyl chloride 
• 74-85-1 ethene 
• 201230-82-2 carbon monoxide 
• 71-23-8 propan-1-ol 

Downstream Products

• 21532-11-6 4-Propyl-2-phenylmorpholin 
• 152192-96-6 (2-hydroxy-ethyl)-propyl-carbamic acid tert-butyl ester 
• 84003-84-9 3,4-bis(benzyloxy)-N-(2-hydroxyethyl)-N-propylbicyclo<4.2.0>octa-1,3,5-triene-7-carboxamide 
• 142363-75-5 2-(3-nitrophenyl)-4-n-propylmorpholine 
• 1224-93-7 5α-androstan-3β-ol 
• 438-22-2 (5α)-androstane 
• 58203-30-8 N-(2-chloroethyl)-N-propylamine hydrochloride 
• 557770-38-4 N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethyl)(propyl)amino]propoxy}-6-methoxyquinazolin-4-yl)amino]-1H-pyrazol-5-yl}acetamide 
• 941702-72-3 C₁₆H₂₂N₂O₇ 
• 850724-03-7 3-[4-(2-propylamino-ethoxy)-phenyl]-propionic acid methyl ester 

Relevant articles and documents

Discovery of benzimidazole analogs as a novel interleukin-5 inhibitors

A series of novel hydroxyethylaminomethylbenzimidazole analogs 5a-y were synthesized and evaluated for their IL-5 inhibitory activity using pro-B Y16 cell line. Among them, 2-(((4-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)amino)butan-1-ol (5e, 94.3% inhibition at 30 μM, IC50 = 3.5 μM, cLogP = 4.132) and 3-cyclohexyl-2-(((4-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)amino) propan-1-ol (5k, 94.7% inhibition at 30 μM, IC50 = 5.0 μM, cLogP = 6.253) showed the most potent inhibitory activity. The essential feature of SAR (Fig. 5) indicated that the chromenone ring can be replaced by a benzimidazole ring to maintain the inhibitory activity. In addition, the hydroxyethylaminomethyl group was suitable for the IL-5 inhibitory activity. Moreover, the hydrophobic substituents on carbon play an important role in the IL-5 inhibitory activity of these analogs. However, N-substituted analogs did not improve inhibitory activity. In addition, MTT assay of 5e and 5k with normal B lymphoblasts revealed that they had no significant effects on cell viability.

METHOD FOR PRODUCING CIS- AND TRANS-ENRICHED MDACH

A process for preparing trans-enriched MDACH, including: distilling an MDACH starting mixture in the presence of an auxiliary, which is an organic compound having a molar mass of 62 to 500 g/mol, a boiling point at least 5° C. above the boiling point of cis,cis-2,6-diamino-1-methylcyclohexane, and 2 to 4 functional groups, each of which is independently an alcohol group or a primary, secondary or tertiary amino group. The MDACH starting mixture includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, based on the total amount of MDACH present in the MDACH starting mixture. The MDACH starting mixture includes both trans and cis isomers. Trans-enriched MDACH includes 0 to 100% by weight of 2,4-MDACH and 0 to 100% by weight of 2,6-MDACH, where the proportion of trans isomers in the mixture is higher than the proportion of trans isomers in the MDACH starting mixture.

Pyrithione biocides enhanced by zinc metal ions and organic amines

The present invention is directed to a stable, soluble, antimicrobial composition concentrate comprising pyrithione or a pyrithione complex in an amount of from about 0.5% to about 30 weight percent, a zinc source in an amount of from about 0.1% to about 10%, and an organic amine component in an amount of from about 30% to about 80%, said percents being based upon the total weight of the composition concentrate. The invention is also directed to methods of controlling the growth of free-living microorganisms or biofilms using the antimicrobial composition of the invention, and products made using the antimicrobial composition of the invention.