164394-36-9

Basic information

• Product Name: Carbamic acid, [(1S,2S)-2,3-dihydroxy-1-(phenylmethyl)propyl]-, phenylmethyl ester
• CAS NO: 164394-36-9
• Molecular Formula: C18H21NO4
• Molecular Weight: 315.369
• Mol File: 164394-36-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S,2S)-2,3-dihydroxy-1-(phenylmethyl)propyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S,2S)-2,3-dihydroxy-1-(phenylmethyl)propyl]-, phenylmethyl ester(164394-36-9)
• EPA Substance Registry System: Carbamic acid, [(1S,2S)-2,3-dihydroxy-1-(phenylmethyl)propyl]-, phenylmethyl ester(164394-36-9)

Safety Data

• Hazardous Substances Data: 164394-36-9(Hazardous Substances Data)

Upstream product

• 59830-60-3 benzyl (1S)-(1-formyl-2-phenylethyl)carbamate 
• 144-55-8 sodium hydrogencarbonate 
• 116949-67-8 (2S,3S)-2-azido-1-phenyl-butane-3,4-diol 
• 78571-81-0 (R,R)-3-(phenylmethyl)oxiranemethanol 
• 501-53-1 benzyl chloroformate 
• 147915-02-4 (2S,3S)-3-amino-4-phenylbutane-1,2-diol 

Downstream Products

• 260562-78-5 ((1S,2R)-1-Benzyl-3-cyano-2-methoxymethoxy-propyl)-methyl-carbamic acid benzyl ester 
• 260562-77-4 ((1S,2R)-1-Benzyl-3-cyano-2-hydroxy-propyl)-methyl-carbamic acid benzyl ester 
• 260562-76-3 Methyl-((S)-1-(S)-oxiranyl-2-phenyl-ethyl)-carbamic acid benzyl ester 
• 174623-90-6 (3R,4R)-4-[(benzyloxycarbonyl)(methyl) amino]-3-(methoxymethoxy)-5-phenylpentanoic Acid 
• 128018-44-0 N-benzyloxycarbonyl-3(S)-amino-1,2(S)epoxy-4-phenylbutane 

Relevant articles and documents

A totally stereocontrolled route to N-methyl-γ-amino-β-hydroxy acids: Asymmetric synthesis of the amino acid component of hapalosin

A new approach to the synthesis of N-methyl-γ-amino-β-hydroxy acids, compounds that are essential components of several depsipeptides exhibiting highly interesting therapeutic profiles, is presented. Relevant steps in the synthetic sequence involve the totally stereoselective preparation of a protected aminoalkyl epoxide from a highly enantiopure 2,3-epoxy alcohol, efficient N-methylation and three-step conversion to the desired N-methyl amino acid. The method is exemplified by the enantioselective synthesis of (3R,4S)-4-(N-methylamino)-3-hydroxy-5-phenylpentanoic acid in two differently protected forms.