260562-76-3

Basic information

• Product Name: Methyl-((S)-1-(S)-oxiranyl-2-phenyl-ethyl)-carbamic acid benzyl ester
• Synonyms: Methyl-((S)-1-(S)-oxiranyl-2-phenyl-ethyl)-carbamic acid benzyl ester
• CAS NO: 260562-76-3
• Molecular Weight: 311.381
• Mol File: 260562-76-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methyl-((S)-1-(S)-oxiranyl-2-phenyl-ethyl)-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-((S)-1-(S)-oxiranyl-2-phenyl-ethyl)-carbamic acid benzyl ester(260562-76-3)
• EPA Substance Registry System: Methyl-((S)-1-(S)-oxiranyl-2-phenyl-ethyl)-carbamic acid benzyl ester(260562-76-3)

Safety Data

• Hazardous Substances Data: 260562-76-3(Hazardous Substances Data)

Upstream product

• 164394-36-9 (2S,3S)-3-(benzyloxycarbonylamino)-4-phenylbutane-1,2-diol 
• 147915-02-4 (2S,3S)-3-amino-4-phenylbutane-1,2-diol 
• 116949-67-8 (2S,3S)-2-azido-1-phenyl-butane-3,4-diol 
• 78571-81-0 (R,R)-3-(phenylmethyl)oxiranemethanol 
• 128018-44-0 N-benzyloxycarbonyl-3(S)-amino-1,2(S)epoxy-4-phenylbutane 
• 74-88-4 methyl iodide 

Downstream Products

• 174623-90-6 (3R,4R)-4-[(benzyloxycarbonyl)(methyl) amino]-3-(methoxymethoxy)-5-phenylpentanoic Acid 
• 260562-78-5 ((1S,2R)-1-Benzyl-3-cyano-2-methoxymethoxy-propyl)-methyl-carbamic acid benzyl ester 
• 260562-77-4 ((1S,2R)-1-Benzyl-3-cyano-2-hydroxy-propyl)-methyl-carbamic acid benzyl ester 

Relevant articles and documents

A totally stereocontrolled route to N-methyl-γ-amino-β-hydroxy acids: Asymmetric synthesis of the amino acid component of hapalosin

A new approach to the synthesis of N-methyl-γ-amino-β-hydroxy acids, compounds that are essential components of several depsipeptides exhibiting highly interesting therapeutic profiles, is presented. Relevant steps in the synthetic sequence involve the totally stereoselective preparation of a protected aminoalkyl epoxide from a highly enantiopure 2,3-epoxy alcohol, efficient N-methylation and three-step conversion to the desired N-methyl amino acid. The method is exemplified by the enantioselective synthesis of (3R,4S)-4-(N-methylamino)-3-hydroxy-5-phenylpentanoic acid in two differently protected forms.