16599-33-0 Usage
Description
2-AMINOETHYL METHANETHIOSULFONATE HYDROBROMIDE (MTSEA) is a pale beige solid that is known for its specific and rapid reaction with thiols to form mixed disulfides. This characteristic makes it a valuable tool in the field of biochemistry and molecular biology for studying the structures and functions of various proteins and channels.
Uses
Used in Biochemistry and Molecular Biology:
2-AMINOETHYL METHANETHIOSULFONATE HYDROBROMIDE (MTSEA) is used as a probe for investigating the structures of different receptor channels, such as the ACh receptor channel, the GABA receptor channel, and lactose permease. Its ability to form mixed disulfides with thiols allows researchers to map the pore-lining regions of these channels, providing insights into their mechanisms of action and potential targets for drug development.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-AMINOETHYL METHANETHIOSULFONATE HYDROBROMIDE (MTSEA) is used as a mapping agent for the ryanodine receptor. By identifying the pore-lining regions of this receptor, researchers can gain a better understanding of its function and develop targeted therapies for conditions related to its dysregulation, such as certain muscle and heart diseases.
Overall, 2-AMINOETHYL METHANETHIOSULFONATE HYDROBROMIDE (MTSEA) plays a crucial role in advancing our knowledge of protein structures and functions, particularly in the context of receptor channels. Its applications in biochemistry, molecular biology, and pharmaceutical research contribute to the development of novel therapeutic strategies and a deeper understanding of biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 16599-33-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,5,9 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16599-33:
(7*1)+(6*6)+(5*5)+(4*9)+(3*9)+(2*3)+(1*3)=140
140 % 10 = 0
So 16599-33-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H9NO2S2/c1-8(5,6)7-3-2-4/h2-4H2,1H3
16599-33-0Relevant articles and documents
Coating Surfaces
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, (2009/12/02)
Disclosed is a method of attaching, indirectly, a member of a specific binding pair (or sbp) to a surface, the method comprising the steps of: (a) contacting the surface with a solution, preferably an aqueous solution, of a polymer, having side chains according to the formula X-Y-Z-R, wherein X is a spacer group; Y is a sulphur, selenium or tellurium atom; Z is a sulphur, selenium or tellurium atom, any of which may be bonded to one or two oxygen atoms; and wherein R is any suitable moiety such that -Z-R constitutes a leaving group; such that at least some of the -Z-R groups are displaced and the polymer becomes bound to the surface by X-Y groups; and (b) contacting a polymer-coated surface resulting from step (a) with a solution, preferably an aqueous solution, comprising an sbp member, so as to cause the polymer to react with the sbp member, so as to attach the sbp member, indirectly, to the surface.
