183235-79-2Relevant articles and documents
Hydrogen bond patterns in solid state carboxylic acids. Vibrational behaviour of the catamer pattern as exhibited by the N-alkyloxamic acids
Wolfs, Ilse,Desseyn, Herman O.
, p. 1521 - 1528 (1996)
The vibrational study presented in this publication shows that the N-alkyloxamic acids are hydrogen bonded through a catamer hydrogen bond pattern in the solid state. Two different hydrogen bond patterns are possible for these products, and these patterns can be very clearly distinguished by their vibrational behaviour. Deuteration and low temperature spectra make the assignment and characterisation more obvious.
Inhibitors of hepatitis C virus NS3·4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics
Perni, Robert B.,Chandorkar, Gurudatt,Cottrell, Kevin M.,Gates, Cynthia A.,Lin, Chao,Lin, Kai,Luong, Yu-Ping,Maxwell, John P.,Murcko, Mark A.,Pitlik, Janos,Rao, Govinda,Schairer, Wayne C.,Drie, John Van,Wei, Yunyi
, p. 3406 - 3411 (2008/02/08)
Reversible tetrapeptide-based compounds have been shown to effectively inhibit the hepatitis C virus NS3·4A protease. Inhibition of viral replicon RNA production in Huh-7 cells has also been demonstrated. We show herein that the inclusion of hydrogen bond donors on the P4 capping group of tetrapeptide-based inhibitors result in increased binding potency to the NS3·4A protease. The capping groups also impart significant effects on the pharmacokinetic profile of these inhibitors.
