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18432-95-6

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18432-95-6 Usage

Description

DICHLORO(1,10-PHENANTHROLINE)PLATINUM(II) is an inorganic platinum complex that features a platinum(II) center coordinated to two chloride ions and a bidentate 1,10-phenanthroline ligand. DICHLORO(1,10-PHENANTHROLINE)PLATINUM(II) is known for its unique coordination chemistry and potential applications in various fields, particularly in catalysis and the synthesis of mixed-metal complexes.

Uses

Used in Inorganic Chemistry:
DICHLORO(1,10-PHENANTHROLINE)PLATINUM(II) is used as a reactant for the synthesis of mixed-metal complexes incorporating platinum and lanthanide centers. Its ability to form stable complexes with other metal ions makes it a valuable precursor in the preparation of heterometallic systems with potential applications in various areas, such as catalysis, magnetism, and luminescence.
Used in Organometallic Chemistry:
This platinum complex is employed as a reactant in the synthesis of platinum complexes containing a chelating di-fluoro-substituted thiourea ligand. The incorporation of such ligands can enhance the stability, reactivity, and selectivity of the resulting organometallic compounds, which can be further explored for applications in homogeneous catalysis and as potential therapeutic agents.
Used in Supramolecular Chemistry:
DICHLORO(1,10-PHENANTHROLINE)PLATINUM(II) is used as a component in the formation of adducts between ternary Pt(III)-amino acid-aromatic diimine complexes and flavin mononucleotide. These adducts can exhibit unique properties, such as enhanced stability and novel photophysical behaviors, which can be exploited in the development of new supramolecular systems and functional materials.
Used in Catalysis:
This platinum complex serves as a catalyst for the selective synthesis of monoorganotin trihalides. Its ability to facilitate the formation of specific organotin compounds with high selectivity makes it a valuable catalyst in the field of organotin chemistry, which has potential applications in various industries, including polymer synthesis, pharmaceuticals, and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 18432-95-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,4,3 and 2 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 18432-95:
(7*1)+(6*8)+(5*4)+(4*3)+(3*2)+(2*9)+(1*5)=116
116 % 10 = 6
So 18432-95-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H8N2.2ClH.Pt/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;;/h1-8H;2*1H;/q;;;+2/p-2

18432-95-6 Well-known Company Product Price

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  • Aldrich

  • (400165)  Dichloro(1,10-phenanthroline)platinum(II)  ≥95.0%

  • 18432-95-6

  • 400165-500MG

  • 1,805.31CNY

  • Detail

18432-95-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name DICHLORO(1,10-PHENANTHROLINE)PLATINUM(II)

1.2 Other means of identification

Product number -
Other names PtII(phen)Cl2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18432-95-6 SDS

18432-95-6Relevant articles and documents

A comparative study of the effects of platinum (Ii) complexes on β-amyloid aggregation: Potential neurodrug applications

La Manna, Sara,Florio, Daniele,Iacobucci, Ilaria,Napolitano, Fabiana,De Benedictis, Ilaria,Malfitano, Anna Maria,Monti, Maria,Ravera, Mauro,Gabano, Elisabetta,Marasco, Daniela

, p. 1 - 13 (2021/03/18)

Herein the effects of three platinum complexes, namely (SP-4-2)-(2,2′-bipyridine)dichlorido platinum(II), Pt-bpy, (SP-4-2)-dichlorido(1,10-phenanthroline) platinum(II), Pt-phen, and (SP-4-2)-chlorido(2,2′:6′,2′ ′-terpyridine)platinum(II) chloride, Pt-terpy, on the aggregation of an amyloid model system derived from the C-terminal domain of Aβ peptide (Aβ21–40) were investigated. Thioflavin T (ThT) binding assays revealed the ability of Pt(II) compounds to repress amyloid aggregation in a dose-dependent way, whereas the ability of Aβ21–40 peptide to interfere with ligand field of metal complexes was analyzed through UV-Vis absorption spectroscopy and electrospray ionization mass spectrometry. Spectroscopic data provided micromolar EC50 values and allowed to assess that the observed inhibition of amyloid aggregation is due to the formation of adducts between Aβ21–40 peptide and complexes upon the release of labile ligands as chloride and that they can explore different modes of coordination toward Aβ21–40 with respect to the entire Aβ1–40 polypeptide. In addition, conformational studies through circular dichroism (CD) spectroscopy suggested that Pt-terpy induces soluble β-structures of monomeric Aβ21–40, thus limiting self-recognition. Noticeably, Pt-terpy demonstrated the ability to reduce the cytotoxicity of amyloid peptide in human SH-SY5Y neuroblastoma cells. Presented data corroborate the hypothesis to enlarge the application field of already known metal-based agents to neurodegenerative diseases, as potential neurodrugs.

Anionic versus neutral Pt(II) complexes: The relevance of the charge for human serum albumin binding

Aiello, Iolinda,Ghedini, Mauro,Guzzi, Rita,Ionescu, Andreea,La Deda, Massimo,Ricciardi, Loredana,Rizzuti, Bruno

, (2020/02/18)

The focus of this work is pointing out the different behavior of two structurally related Pt(II) complexes, the anionic cyclometalated NBu4[(Bzq)Pt(Thio)], 1 and the neutral [(Phen)Pt(Thio)], 2, (Bzq = benzo[h]quinoline, Phen = 1,10-phenantroline, Thio = 1,2-benzenedithiolate), on the interaction with human serum albumin (HSA), a key drug-delivery protein in the bloodstream. Being very limited the number of anionic Pt(II) complexes reported to date, this is a pioneering example of report on a protein-ligand interaction involving a negatively charged platinum compound. The study was carried out by using fluorescence spectroscopy, differential scanning calorimetry and molecular docking simulations. The results revealed a strong binding affinity between the anionic compound and the protein, whereas a weak/moderate binding interaction was highlighted for the neutral one. Comparative studies with site specific ligands (warfarin and ibuprofen), allowed us to identify the protein binding sites of the two compounds. The work aims to shed light on the relevance of the charge in designing new drugs with a favorable binding affinity for HSA, which strongly contributes to influence their pharmacological and toxicological profile.

Conformational analysis and potential anticancer activity of [Pt(phen)(L1 -κ: S)2] studied by single crystal X-ray diffraction and variable temperature 1H and 195Pt NMR spectroscopy

Kangara, Edmore F.,Peega, Tebogo,Harmse, Leonie,Van Wyk, Juanita L.,Levendis, Demetrius C.,Kotzé, Izak A.

, p. 3665 - 3672 (2019/03/05)

The mixed-ligand [Pt(phen)(L1-κS)2] complex, in which two N,N-diethyl-N′-1-naphthoylthioureato ligands (L1)- coordinate in an unusual κS-thio/amido mode, crystallises in two solvatomorphs, form I and form II, whose structures have been determined by single crystal X-ray diffraction. These crystals were obtained from tetrahydrofuran and methanol/water respectively showing interesting sandwich (form I) and half-sandwich (form II) intramolecular π-stacking arrangements between the naphthoyl moiety of the acylthioureato ligands and the 1,10-phenanthroline ligand that adopt an anti-conformation above and below the square planar coordination plane. Variable temperature 1H and 195Pt NMR spectroscopy showed that these π-stacking arrangements persist in methanol solution especially at lower temperatures, where significant chemical shift shielding and asymmetry are observed indicating at least 3 conformers at -50 °C. A preliminary study indicates that this new compound may have potential as a new anticancer agent since it is active against the A549 lung cancer cell-line with an IC50 value of 6 ± 0.9 μM.

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