18487-39-3

Basic information

• Product Name: 2,3,5-trichloroaniline
• Synonyms: 2,3,5-trichloroaniline;2,3,5-Trichlorobenzenamine;Benzenamine, 2,3,5-trichloro-;Einecs 242-373-4
• CAS NO: 18487-39-3
• Molecular Formula: C₆H₄Cl₃N
• Molecular Weight: 196.46166
• EINECS: 242-373-4
• Mol File: 18487-39-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 73 °C
• Boiling Point: 286°Cat760mmHg
• Flash Point: 126.8°C
• Appearance: /
• Density: 1.54g/cm³
• Vapor Pressure: 0.00271mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.54±0.10(Predicted)
• CAS DataBase Reference: 2,3,5-trichloroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5-trichloroaniline(18487-39-3)
• EPA Substance Registry System: 2,3,5-trichloroaniline(18487-39-3)

Safety Data

• Hazardous Substances Data: 18487-39-3(Hazardous Substances Data)

Usage

General Description

2,3,5-trichloroaniline is a chemical compound with the molecular formula C6H4Cl3N. It is a white to light brown solid with a distinctive odor and is insoluble in water. 2,3,5-trichloroaniline is primarily used in the manufacturing of dyes, pigments, and pharmaceuticals. It is also used as an intermediate in the production of agricultural chemicals and as a corrosion inhibitor in metalworking fluids. While it has some industrial uses, 2,3,5-trichloroaniline is considered to be hazardous to human health and the environment, and exposure to it should be limited and carefully controlled.

InChI:InChI=1/C6H4Cl3N/c7-3-1-4(8)6(9)5(10)2-3/h1-2H,10H2

Upstream product

• 34283-94-8 2,3,5-trichloronitrobenzene 
• 64-19-7 acetic acid 
• 626-43-7 3,5-Dichloroaniline 
• 825-41-2 3-chloro-4-nitroaniline 
• 588-07-8 3-Chloroacetanilide 
• 62406-69-3 2,3,6-trichloro-4-nitro-aniline 

Downstream Products

• 933-78-8 2,3,5-trichlorophenol 
• 3107-20-8 2,3,5-Trichlorfluorbenzol 
• 216393-66-7 1,2,5-trichloro-3-iodobenzene 
• 71511-82-5 3,4-dimethyl-4-(2,3,5-trichloro-phenylazo)-4H-isoxazol-5-one 
• 86282-71-5 2-(2,3,5-Trichloro-phenylamino)-benzoic acid 
• 52663-61-3 2,2'3,5,5'-pentachlorobiphenyl 
• 68194-17-2 2,2',3,3',4,5,5',6-octachlorobiphenyl 
• 68194-07-0 2,2',3,4',5-pentachlorobiphenyl 
• 39635-34-2 2,3,3',4',5,5'-hexachlorobiphenyl 
• 55720-44-0 2,3,5-trichlorobiphenyl 
• 54135-81-8 2,3,5-trichloroanisole 
• 38411-20-0 1,2,4-trichloro-3-iodobenzene 
• 626-43-7 3,5-Dichloroaniline 
• 78965-97-6 2,3,5-trichlorobenzenediazonium trichloromercurate(II) 

Relevant articles and documents

Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma

A growing number of studies have reported phenolic halogenated compounds (PHCs) that are retained in the blood of humans and wildlife. These PHCs may be industrial chemicals; metabolites thereof, as in the case with polychlorobiphenylols (OH-PCBs); or of natural origin. The present study was aimed to identify hitherto unknown PHCs in human plasma with chemical structures that are consistent to PHCs known to possess endocrine-disrupting activity. For this purpose, samples of blood plasma from 10 randomly selected male blood donors from Sweden were pooled and analyzed by GC/ECD and GC/MS. Brominated, bromochlorinated, and chlorinated methyl derivatives of phenols and OH-PCBs were synthesized to be used as authentic reference standards. More than 100 PHCs were indicated in the plasma, and among those a total of 9 monocyclic brominated or chlorinated phenol-, guaiacol-, and/or catechol-type compounds were identified as their methylated derivatives. The two major compounds were 2,4,6-tribromophenol and pentachlorophenol. Thirty-eight OH-PCB congeners were structurally identified on two GC columns of different polarity. The origin of the OH-PCB metabolites in the context of their parent PCB congeners are suggested. Other PHCs identified in the male plasma were Triclosan (5-chloro-2-[2,4-dichlorophenoxy] phenol), a common bactericide; 4-hydroxy-heptachlorostyrene, a metabolite of octachlorostyrene; and 3,5-dibromo-2-(2,4-dibromophenoxy)phenol, a natural compound and a potential metabolite of polybrominated diphenyl ethers.