18732-64-4

Basic information

• Product Name: 2-benzyl-4,5-dihydro-thiazole
• Synonyms: 2-benzyl-4,5-dihydro-thiazole
• CAS NO: 18732-64-4
• Molecular Weight: 177.27
• Mol File: 18732-64-4.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-benzyl-4,5-dihydro-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-4,5-dihydro-thiazole(18732-64-4)
• EPA Substance Registry System: 2-benzyl-4,5-dihydro-thiazole(18732-64-4)

Safety Data

• Hazardous Substances Data: 18732-64-4(Hazardous Substances Data)

Upstream product

• 140-29-4 phenylacetonitrile 
• 60-23-1 Cysteamine 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 645-54-5 2-phenylthioacetamide 
• 19975-56-5 2-methylsulfanyl-4,5-dihydrothiazoline 
• 62673-31-8 benzyl(bromo)zinc 
• 861058-36-8 2-(2-phenylacetamido)ethyl acetate 
• 6269-99-4 N-(2-hydroxyethyl)-2-phenylacetamide 
• 103-80-0 phenylacetyl chloride 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 103-82-2 phenylacetic acid 
• 141-43-5 ethanolamine 
• 101-97-3 Ethyl 2-phenylethanoate 
• 23547-02-6 N-(2-chloroethyl)phenylacetamide 

Downstream Products

• 40051-95-4 3-(N-benzoyl-glycyl)-2-benzylidene-thiazolidine 
• 40052-06-0 N-benzoyl-thioglycine S-{2-[1-(5-oxo-2-phenyl-oxazol-4-ylidene)-2-phenyl-ethylamino]-ethyl} ester 
• 13146-75-3 8a-Benzyl-5,7-dioxo-2,3,5,6,7,8,8a-heptahydro-thiazolo <3.2-a>-s-triazin 
• 69690-63-7 (2-benzylidene-thiazolidin-3-yl)-fumaric acid dimethyl ester 
• 76177-10-1 N-(2-mercaptoethyl)-2-phenylacetamide 
• 1384256-53-4 3-ethyl-1-[2-(6-ethyl-5-oxo-7-phenyl-2,3,5,7a-tetrahydropyrrolo[2,1-b]thiazol-7a-ylthio)ethyl]-4-phenyl-1H-pyrrole-2,5-dione 
• 1384256-55-6 (7aR,7'aS)-6,6'-diethyl-7,7'-diphenyl-2H,2'H-7a,7'a-bipyrrolo[2,1-b]thiazole-5,5'(3H,3'H)-dione 
• 1384256-52-3 1,1'-(2,2'-disulfanediylbis(ethane-2,1-diyl))bis(3-ethyl-4-phenyl-1H-pyrrole-2,5-dione) 
• 1384256-36-3 (Z)-3-(2,2-dichlorobutanoyl)-2-benzylidenethiazolidine 
• 7210-75-5 1,3-Thiazol-2-yl phenyl ketone 
• 58861-63-5 (4,5-dihydrothiazol-2-yl)(phenyl)methanone 
• 40052-09-3 4-[1-(2-mercapto-ethylamino)-2-phenyl-ethylidene]-3-phenyl-4H-isoxazol-5-one 

Relevant articles and documents

A one step synthesis of thiazolines from esters

Condensation of the triisobutylaluminum complex of cysteamine HCl with a variety of carboxylic esters furnishes thiazolines in one step. This new method has been applied to chiral α-aminoesters to give α-amino thiazolines of high optical purity, yet N-ben

Additive-free pd-catalyzed α-allylation of imine-containing heterocycles

An additive-free Pd-catalyzed α-allylation of different imino-group-ontaining heterocycles is reported. The activation of α-CH pronucleophiles (pKa (DMSO) > 25) occurs without the addition of strong bases or Lewis acids using only the Pd/Xantphos catalyst system. The reaction scope has been studied for various 5- and 6-membered nitrogen-containing heterocycles (yields up to 96%). Mechanistic investigations suggest an initial allylation of the imine-N followed by a Pd-catalyzed formal aza-Claisen rearrangement.

DDQ-induced dehydrogenation of heterocycles for c-c double bond formation: Synthesis of 2-thiazoles and 2-oxazoles

Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.