187402-80-8

Basic information

• Product Name: 2,3,4,5,6-pentafluorophenyl 4-cyanobenzoate
• Synonyms: 2,3,4,5,6-pentafluorophenyl 4-cyanobenzoate
• CAS NO: 187402-80-8
• Molecular Weight: 313.183
• Mol File: 187402-80-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,3,4,5,6-pentafluorophenyl 4-cyanobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5,6-pentafluorophenyl 4-cyanobenzoate(187402-80-8)
• EPA Substance Registry System: 2,3,4,5,6-pentafluorophenyl 4-cyanobenzoate(187402-80-8)

Safety Data

• Hazardous Substances Data: 187402-80-8(Hazardous Substances Data)

Upstream product

• 105-07-7 4-cyanobenzaldehyde 
• 188837-53-8 (2,3,4,5,6-pentafluorophenyl)pyridine-2-carboxylate 
• 201230-82-2 carbon monoxide 
• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 623-00-7 4-bromobenzenecarbonitrile 

Downstream Products

• 17847-33-5 phenyl 4-cyanobenzoate 
• 95725-03-4 4-cyano-N,N-diethylbenzamide 
• 17922-96-2 4-cyanobenzanilide 
• 24167-50-8 4-cyano-N,N-dimethylbenzamide 
• 150057-96-8 4-(pyrrolidine-1-carbonyl)benzonitrile 

Relevant articles and documents

General method for the preparation of active esters by palladium-catalyzed alkoxycarbonylation of aryl bromides

A useful method was developed for the synthesis of active esters by palladium-catalyzed alkoxycarbonylation of (hetero)aromatic bromides. The protocol was general for a range of oxygen nucleophiles including N-hydroxysuccinimide (NHS), pentafluorophenol (PFP), hexafluoroisopropyl alcohol (HFP), 4-nitrophenol, and N-hydroxyphthalimide. A high functional group tolerance was displayed, and several active esters were prepared with good to excellent isolated yields. The protocol was extended to access an important synthetic precursor to the HIV-protease inhibitor, saquinavir, by formation of an NHS ester followed by acyl substitution.