188053-41-0Relevant articles and documents
Synthesis and conformational behaviour of 2-phenylperhydropyrrolo[1,2-4][1,3,4]oxadiazine and 2-phenylperhydropyrido[1,2-d][1,3,4]oxadiazine; new heterocyclic ring systems
Rosling, Ari,Fueloep, Ferenc,Sillanpaeae, Reijo,Mattinen, Jorma
, p. 95 - 106 (2007/10/03)
Hydrazino alcohols, 1-amino-2-hydroxymethylpyrrolidine (1) and 1-amino-2-hydroxymethylpiperidine (2), were synthesized and subsequently ring closured with ethyl benzimidate to the title compounds (7) and (8), which have new ring systems. Variabletemperature 1H nmr measurements, supported by X-ray analysis, indicated that pyrrolo[1,2-d][1,3,4]oxadiazine (7) exists exclusively in a cis-fused conformation (in CDCl3 at room temperature), whereas pyrido[1,2-d][1,3,4]oxadiazine (8) adopts a trans-fused conformation.