1885-13-8

Basic information

• Product Name: 4-Methoxyphthalic acid
• Synonyms: RARECHEM AL BO 1743;4-METHOXYPHTHALIC ACID;AKOS 212-42;4-METHOXYPHTALIC ACID;4-METHOXYPHTHALIC ACID,98+%;4-Methoxybenzene-1,2-dicarboxylic acid;Phthalic acid, 4-methoxy-
• CAS NO: 1885-13-8
• Molecular Formula: C₉H₈O₅
• Molecular Weight: 196.16
• EINECS: 217-546-2
• Mol File: 1885-13-8.mol
• Article Data: 25

Chemical Properties

• Melting Point: 178 °C(Solv: water (7732-18-5))
• Boiling Point: 394.036 °C at 760 mmHg
• Flash Point: 162.894 °C
• Appearance: /
• Density: 1.416 g/cm³
• Vapor Pressure: 6.46E-07mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: almost transparency in Methanol
• PKA: 3.13±0.10(Predicted)
• CAS DataBase Reference: 4-Methoxyphthalic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxyphthalic acid(1885-13-8)
• EPA Substance Registry System: 4-Methoxyphthalic acid(1885-13-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 1885-13-8(Hazardous Substances Data)

Usage

General Description

4-Methoxyphthalic acid is a chemical compound with the molecular formula C9H8O5. It is a white crystalline powder that is soluble in water and organic solvents. 4-Methoxyphthalic acid is often used in the production of dyes and pigments, as well as in the synthesis of pharmaceuticals and other organic compounds. It is also used as a building block in the creation of polymers and resins. 4-Methoxyphthalic acid has been found to have potential antimicrobial and antioxidant properties, making it valuable in the development of various industrial and consumer products. Additionally, it is considered to have low toxicity and is generally regarded as safe for use in the intended applications.

InChI:InChI=1/C9H8O5/c1-14-5-2-3-6(8(10)11)7(4-5)9(12)13/h2-4H,1H3,(H,10,11)(H,12,13)

Upstream product

• 4741-63-3 6-methoxyphthalide 
• 4685-47-6 3,4-dimethylanisole 
• 5111-69-3 5-methoxyindane 
• 57-62-5 Chlortetracycline 
• 22895-19-8 dimethyl 4-methoxyphtalate 
• 6245-57-4 4-methoxy-2-methylbenzoic acid 
• 3168-59-0 5-methoxy-o-toluic acid 
• 22811-86-5 1,7-Bis-(4-methoxy-2-methyl-phenyl)-heptane-1,7-dione 
• 1730-48-9 6-methoxy-1,2,3,4-tetrahydronaphthalene 
• 610-35-5 4-hydroxyphthalic acid 
• 77-78-1 dimethyl sulfate 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 82894-69-7 6-methoxy-1,4-diphenylisoquinoline 
• 1596-15-2 (S)-Cyclohexyl-4-methoxy-2-methyl-benzene 

Downstream Products

• 28281-76-7 5-methoxyisobenzofuran-1,3-dione 
• 610-35-5 4-hydroxyphthalic acid 
• 98589-66-3 4-methoxy-3-nitro-phthalic acid 
• 408339-12-8 4-methoxy-5-nitro-phthalic acid 
• 201287-73-2 4-methoxy-3-nitro-phthalic acid monomethyl ester 
• 856806-20-7 4-methoxy-5-nitro-phthalic acid dimethyl ester 
• 50727-04-3 4-methoxyphthalimide 
• 36132-95-3 (2-hydroxymethyl-5-methoxy-phenyl)-methanol 
• 36132-96-4 1,2-bis(bromomethyl)-4-methoxybenzene 
• 36132-97-5 4-methoxy-1,2-benzenediacetonitrile 
• 22246-66-8 6-methoxy-2,3-dihydro-isoindol-1-one 
• 1089667-07-1 5-methoxy-2-(4-nitrophenyl)isoindol-1,3-dione 
• 1310530-55-2 5-{1-tert-butyl-2-[5-methoxy-2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine 
• 1035797-89-7 2-chlorocarbonyl-5-methoxybenzoic acid methyl ester 

Relevant articles and documents

NOVEL BROMINATED FURANONE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a novel brominated furanone derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient, wherein the novel brominated furanone derivative or a pharmaceutically acceptable 5 salt thereof according to the present invention exhibits a quorum sensing inhibitory activity of bacteria and also can effectively inhibit the formation of biofilm of bacteria, and thus can be used as a pharmaceutical composition containing the same as an active ingredient, thereby having an effect of being useful, 10 for example, for periodontal diseases such as gingivitis and periodontitis, oral diseases, and the like.

Synthesis, biological evaluation and molecular modeling studies of phthalazin-1(2: H)-one derivatives as novel cholinesterase inhibitors

A new series of donepezil analogues based on the phthalazin-1(2H)-one scaffold was designed and synthesized with the aim of exploring its potential as human ChEIs. Biological results revealed that the structural modifications proposed significantly affected ChE inhibitory potency as well as selectivity for AChE/BuChE. Compound 1d showed promising in vitro inhibition of both enzymes in the μM range. However, most target compounds were significantly more active against AChE than BuChE, specifically 1f, 1h and 1j, with IC50 values in the low micromolar or submicromolar range, the most active compounds in the series. Docking simulations suggested that the most active compounds can recognize the donepezil binding site using a similar interactions network. These results allowed us to rationalize the observed structure-activity relationships. Moreover, the predicted physicochemical and ADME properties were also comparable to those of donepezil.