19132-98-0

Basic information

• Product Name: 4-DIMETHYLAMINO-4'-METHYLCHALCONE
• Synonyms: 4-DIMETHYLAMINO-4'-METHYLCHALCONE;OMEGA-(P-DIMETHYLAMINOBENZYLIDENE)-4-METHYL ACETOPHENONE
• CAS NO: 19132-98-0
• Molecular Formula: C₁₈H₁₉NO
• Molecular Weight: 265.35
• Product Categories: Chalcones
• Mol File: 19132-98-0.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 439.6°Cat760mmHg
• Flash Point: 171°C
• Appearance: /
• Density: 1.087g/cm³
• CAS DataBase Reference: 4-DIMETHYLAMINO-4'-METHYLCHALCONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-DIMETHYLAMINO-4'-METHYLCHALCONE(19132-98-0)
• EPA Substance Registry System: 4-DIMETHYLAMINO-4'-METHYLCHALCONE(19132-98-0)

Safety Data

• Hazardous Substances Data: 19132-98-0(Hazardous Substances Data)

Upstream product

• 122-00-9 para-methylacetophenone 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 20972-36-5 4-(p-methylphenyl)-4-oxo-2-butenoic acid 
• 28611-39-4 4-(dimethylamino)benzene-boronic acid 

Downstream Products

• 96954-50-6 7-(4-methylphenyl)-2-thioxopyrido[2,3-d]pyrimidin-4-one 
• 96667-93-5 N,N-dimethyl-4-(2-phenyl-5-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-aniline 
• 1127227-23-9 4-[4-(dimethylamino)phenyl]-6-(4-methylphenyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 1204687-49-9 C₃₀H₂₉N₅ 
• 1262326-38-4 3-(4-methylphenyl)-5-(4-dimethylaminophenyl)-2-pyrazoline 
• 1393930-73-8 1-(2,3,5,6-tetrafluoro-4-bromophenyl)-3-(4-methylphenyl)-5-(4-(dimethylamino)phenyl)-2-(4,5-dihydropyrazoline) 
• 1606142-51-1 3-(2-aminophenythio)-3-(4-dimethylamino)phenyl-1-p-tolylpropan-1-one 
• 1616890-19-7 2-[4-(dimethylamino)phenyl]-4-oxo-4-p-tolylbutanenitrile 

Relevant articles and documents

Photophysical study and biological applications of synthetic chalcone-based fluorescent dyes

A chalcone series (3a–f) with electron push–pull effect was synthesized via a one-pot Claisen–Schmidt reaction with a simple purification step. The compounds exhibited strong emission, peaking around 512–567 nm with mega-stokes shift (?λ = 93–139 nm) in p

Pyrazoline analogs as potential anticancer agents and their apoptosis, molecular docking, MD simulation, DNA binding and antioxidant studies

N-formyl pyrazoline derivatives (3a–3l) were designed and synthesized via Michael addition reaction through cyclization of chalcones with hydrazine hydrate in presence of formic acid. The structural elucidation of N-formyl pyrazoline derivatives was carri

Silica-supported heterogeneous catalysts-mediated synthesis of chalcones as potent urease inhibitors: in vitro and molecular docking studies

Abstract: We herein report a facile and high yielding protocol for silica-supported heterogeneous catalysts-mediated synthesis of chalcones. A comparison of results of our synthesis with conventional synthetic protocols is also being offered to assess the efficiency of the prepared catalysts. Biological evaluation of the newly synthesized compounds as urease inhibitors was performed. Most of the compounds were found to have potent urease inhibition activity. The chalcone 3-(3-hydroxyphenyl)-1-phenylpropenone was found to be the most potent with percentage inhibition 86.17 ± 0.89 and half maximal inhibitory concentration (IC50) value 11.51 ± 0.03 μM. The molecular docking study emphasized that the same congeners 3-(furan-2-yl)-1-(4-hydroxyphenyl)propenone, 3-(4-hydroxyphenyl)-1-(4-methoxyphenyl)propanone, and 3-[4-(dimethylamino)phenyl]-1-(p-tolyl)propenone showed very good inhibitory potential against urease and show a higher docking scores 5718, 5940, 5596 and an ACE of ? 246.66, ? 244.79, and ? 243.06 kJ/mol, respectively than the control ligand. Graphic abstract: [Figure not available: see fulltext.].