19434-30-1

Basic information

• Product Name: (2-hydroxyphenyl)(4-methylphenyl)methanone
• CAS NO: 19434-30-1
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.2439
• Mol File: 19434-30-1.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 344.4°C at 760 mmHg
• Flash Point: 146.6°C
• Density: 1.164g/cm³
• Vapor Pressure: 3.32E-05mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: (2-hydroxyphenyl)(4-methylphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-hydroxyphenyl)(4-methylphenyl)methanone(19434-30-1)
• EPA Substance Registry System: (2-hydroxyphenyl)(4-methylphenyl)methanone(19434-30-1)

Safety Data

• Hazardous Substances Data: 19434-30-1(Hazardous Substances Data)

Usage

Description

(2-hydroxyphenyl)(4-methylphenyl)methanone is a chemical compound that consists of a phenyl group with a hydroxy group attached at the 2 position and a methyl group at the 4 position. It also contains a methanone functional group, which is a carbonyl group attached to a carbon atom.

Uses

Used in Pharmaceutical and Chemical Industries:
(2-hydroxyphenyl)(4-methylphenyl)methanone is used as a reagent in various organic synthesis reactions for its unique chemical structure.
Used in Sunscreen Products:
(2-hydroxyphenyl)(4-methylphenyl)methanone is used as an antioxidant in the production of sunscreen products to protect against harmful UV radiation.
Used in Drug Development:
(2-hydroxyphenyl)(4-methylphenyl)methanone has potential applications in the development of novel drugs and pharmaceutical compounds due to its unique chemical structure.

Upstream product

• 75919-94-7 (5-(tert-butyl)-2-hydroxyphenyl)(p-tolyl)methanone 
• 102162-08-3 5-tert-butyl-2-methoxy-4'-methyl-benzophenone 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 108-88-3 toluene 
• 1900-85-2 phenyl p-methylbenzoate 
• 141368-26-5 2-N-(p-methylbenzenesulfonyl)amino-4'-methyl-benzophenone 
• 133366-98-0 2-(allyloxy)-4'-methylbenzophenone 
• 89-95-2 2-methyl-benzyl alcohol 
• 46449-56-3 4,4'-dimethyldiphenyliodonium cation 
• 46340-49-2 Phenyl-p-tolyliodoniumsalz 
• 7664-93-9 sulfuric acid 
• 64-17-5 ethanol 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 64-19-7 acetic acid 

Downstream Products

• 27827-60-7 6-p-tolyl-3,4-dihydro-2H-benzo[b][1,5]oxazocin-3-ol 
• 133366-98-0 2-(allyloxy)-4'-methylbenzophenone 
• 116544-58-2 [2-(4-Methyl-benzoyl)-phenoxy]-phenyl-acetic acid ethyl ester 
• 100-21-0 terephthalic acid 
• 28137-36-2 (2-methoxyphenyl)(4-methylphenyl)methanone 
• 35307-35-8 2-phenyl-3-(4-methylphenyl)benzofuran 
• 116544-68-4 [2-(4-Methyl-benzoyl)-phenoxy]-phenyl-acetic acid 
• 142016-35-1 2-cyanomethoxy-4'-methylbenzophenone 
• 1003959-93-0 (2-((1-ethoxycarbonyl-1,1-dimethylmethyl)oxy)phenyl)(p-tolyl)methanone 
• 1279131-11-1 (S)-2-(p-tolyl((3,4,5-trimethoxyphenyl)amino)methyl)phenol 
• 1279130-88-9 (E)-2-(p-tolyl((3,4,5-trimethoxyphenyl)imino)methyl)phenol 
• 1334247-21-0 (S)-2-(amino(p-tolyl)methyl)phenol 
• 1374329-60-8 3-acetyl-4-(p-tolyl)-2H-chromen-2-one 

Relevant articles and documents

Water-Tolerant ortho-Acylation of Phenols

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

Eco-friendly organocatalyst- And reagent-controlled selective construction of diverse and multifunctionalized 2-hydroxybenzophenone frameworks for potent UV-A/B filters by cascade benzannulation

The organocatalyst- and reagent-controlled highly selective synthesis of diversely functionalized novel 2-hydroxybenzophenone frameworks, such as 2-hydroxy-3′-formylbenzophenones, 7-(2′-hydroxybenzoyl)-2-naphthaldehydes, and 2-hydroxybenzophenones, under green conditions, for the development of potent UV-A/B filters is described. The organocatalyzed benzannulation reactions proceed individually via [3 + 3] cycloaddition for the synthesis of 2-hydroxy-3′-formylbenzophenones and [4 + 2] cycloaddition for 2-hydroxybenzophenones. With this methodology, an unprecedented double benzannulation allows one-pot construction of diverse 7-(2′-hydroxybenzoyl)-2-naphthaldehydes via [3 + 3 + 4] cycloaddition. This protocol features a broad substrate scope, high functional-group tolerance, and operational simplicity in an environmentally benign green solvent. The synthesized compounds are successfully utilized for further transformations and well characterized as potent UV-A/B filters.

Cu/Ag mediated peroxide-free synthesis of benzoylated naphthol derivatives

A peroxide-free methodology was developed for the synthesis of benzoylated naphthol/phenol derivatives through oxidative deamination reaction performed under aerobic reaction conditions. A synergistic combination of Cu(OTf)2 and Ag2O was used to convert the aminonaphthols and aminophenols to the corresponding benzoylated derivatives. The definite role of atmospheric oxygen to assist the reaction was proved by performing the reaction in the argon atmosphere.