194367-71-0

Basic information

• Product Name: (3R,4β,7α)-7-(4-chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-[4-(phenylMethoxy)phenyl]-2-azaspiro[3.5]nonan-1-one
• Synonyms: (3R,4β,7α)-7-(4-chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-[4-(phenylMethoxy)phenyl]-2-azaspiro[3.5]nonan-1-one;Sch 58053 Benzyl Ether
• CAS NO: 194367-71-0
• Molecular Formula: C₃₃H₂₉ClFNO₃
• Molecular Weight: 542.0396632
• Mol File: 194367-71-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (3R,4β,7α)-7-(4-chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-[4-(phenylMethoxy)phenyl]-2-azaspiro[3.5]nonan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4β,7α)-7-(4-chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-[4-(phenylMethoxy)phenyl]-2-azaspiro[3.5]nonan-1-one(194367-71-0)
• EPA Substance Registry System: (3R,4β,7α)-7-(4-chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-[4-(phenylMethoxy)phenyl]-2-azaspiro[3.5]nonan-1-one(194367-71-0)

Safety Data

• Hazardous Substances Data: 194367-71-0(Hazardous Substances Data)

Usage

Description

(3R,4β,7α)-7-(4-chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-[4-(phenylMethoxy)phenyl]-2-azaspiro[3.5]nonan-1-one is a complex organic compound with a unique molecular structure. It is characterized by its 2-azaspiro[3.5]nonan-1-one core, which is fused with a 3.5-nonane ring. The molecule features a 7-hydroxy group, a 4-chlorophenyl group at the 7-position, a 4-fluorophenyl group at the 2-position, and a phenylmethoxyphenyl group at the 3-position. (3R,4β,7α)-7-(4-chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-[4-(phenylMethoxy)phenyl]-2-azaspiro[3.5]nonan-1-one is an analog of Ezetimibe, a drug used to treat high cholesterol.

Uses

Used in Pharmaceutical Industry:
(3R,4β,7α)-7-(4-chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-[4-(phenylMethoxy)phenyl]-2-azaspiro[3.5]nonan-1-one is used as a cholesterol-lowering agent for the treatment of hypercholesterolemia. As an analog of Ezetimibe, it works by inhibiting the absorption of cholesterol in the small intestine, thereby reducing the levels of low-density lipoprotein cholesterol (LDL-C) in the blood.
Used in Drug Development:
(3R,4β,7α)-7-(4-chlorophenyl)-2-(4-fluorophenyl)-7-hydroxy-3-[4-(phenylMethoxy)phenyl]-2-azaspiro[3.5]nonan-1-one is used in drug development as a potential candidate for the treatment of other lipid metabolism-related disorders. Its unique structure and properties make it a valuable compound for further research and development in the pharmaceutical industry.

Upstream product

• 182227-24-3 1-[(S)-(4-Benzyloxy-phenyl)-hydroxy-methyl]-4-oxo-cyclohexanecarboxylic acid (4-fluoro-phenyl)-amide 
• 182227-19-6 8-[(S)-(4-Benzyloxy-phenyl)-hydroxy-methyl]-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester 
• 182227-16-3 [(1,4-Dioxa-spiro[4.5]dec-8-ylidene)-ethoxy-methoxy]-trimethyl-silane 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 1489-97-0 ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 194367-70-9 (+)-(R)-2-(4-fluorophenyl)-3-(4-(benzyloxy)phenyl)-2-azaspiro[3.5]nonane-1,7-dione 

Downstream Products

• 194423-53-5 (R)-7-(4-Chloro-phenyl)-2-(4-fluoro-phenyl)-7-hydroxy-3-(4-hydroxy-phenyl)-2-aza-spiro[3.5]nonan-1-one 

Relevant articles and documents

A Catalytic Asymmetric Synthesis of a Spirofused Azetidinone as a Cholesterol Absorption Inhibitor

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