20120-21-2

Basic information

• Product Name: 3-DIETHYLAMINOPROPIONIC ACID ETHYL ESTER
• Synonyms: ETHYL BETA-DIETHYLAMINO PROPIONATE;ETHYL 3-DIMETHYLAMINOPROPIONATE;ETHYL 3-(DIETHYLAMINO)PROPANOATE;ETHYL 3-DIETHYLAMINOPROPIONATE;N,N-DIETHYL-BETA-ALANINE ETHYL ESTER;N,N-DIMETHYL-BETA-ALANINE ETHYL ESTER;ethyl N,N-dimethyl-beta-alaninate;3-dimethylaminopropionate
• CAS NO: 20120-21-2
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 173.25
• EINECS: 243-524-7
• Mol File: 20120-21-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 56-57°C 12mm
• Flash Point: 58°C
• Appearance: /
• Density: 0,915 g/cm3
• Vapor Pressure: 0.148mmHg at 25°C
• Refractive Index: 1.4190
• PKA: 8.83±0.28(Predicted)
• Water Solubility: Immiscible with water.
• BRN: 1702477
• CAS DataBase Reference: 3-DIETHYLAMINOPROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-DIETHYLAMINOPROPIONIC ACID ETHYL ESTER(20120-21-2)
• EPA Substance Registry System: 3-DIETHYLAMINOPROPIONIC ACID ETHYL ESTER(20120-21-2)

Safety Data

• Statements: 36/37/38-10
• Safety Statements: 26-36
• RIDADR: 1993
• RTECS: AY5992700
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 20120-21-2(Hazardous Substances Data)

Usage

Description

3-DIETHYLAMINOPROPIONIC ACID ETHYL ESTER, also known as Ethyl 3-dimethylaminopropionate, is a chemical compound with the molecular formula C8H16NO2. It is an ester derivative of 3-dimethylaminopropionic acid and possesses a basic nitrogen atom in its structure. 3-DIETHYLAMINOPROPIONIC ACID ETHYL ESTER is known for its unique chemical properties and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
3-DIETHYLAMINOPROPIONIC ACID ETHYL ESTER is used as an intermediate compound for the synthesis of [3-(dimethylamino)propionyl]guanidine. This synthesized compound has potential applications in the development of pharmaceuticals, particularly those targeting cardiovascular and neurological disorders. The ester group in Ethyl 3-dimethylaminopropionate allows for further chemical modifications and functionalization, making it a versatile building block in the synthesis of various drug candidates.

InChI:InChI=1/C9H19NO2/c1-4-10(5-2)8-7-9(11)12-6-3/h4-8H2,1-3H3

Upstream product

• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 
• 927-80-0 1-ethoxyacetylene 
• 140-88-5 ethyl acrylate 
• 56275-84-4 N-(butoxymethyl)dimethylamine 
• 65946-52-3 1-Ethoxy-1-trimethylsilyloxy-1-buten 
• 539-74-2 Ethyl 3-bromopropionate 
• 50283-25-5 catechol diacrylate 
• 7732-18-5 water 
• 92-84-2 10H-phenothiazine 
• 150-76-5 4-methoxy-phenol 
• 3586-58-1 2-methylenebutyric acid 

Downstream Products

• 4320-42-7 3-dimethylamino-1,1-diphenyl-propan-1-ol 
• 130515-23-0 methyl 2-(dimethylamino)propanoate ? 
• 25363-28-4 1-(Dimethylaminoethyl)-cyclohexanol-⁽¹⁾ 
• 22636-79-9 3-(dimethylamino)propanehydrazide 
• 85594-19-0 3-Dimethylammonio-propionylhydroxamsaeure 
• 3699-67-0 ethyl 3-(diethoxyphosphoryl)propanoate 
• 145398-27-2 Toluene-4-sulfonate(2-ethoxycarbonyl-ethyl)-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-2-hydroxy-decyl)-dimethyl-ammonium; 
• 19075-26-4 ethyl (trimethylammonio)propionate iodide 
• 23577-37-9 2-Benzyl-4-dimethylamino-1-phenylbutan-2-ol 
• 2409-52-1 diethylitaconate 
• 90696-19-8 cis-3-((dimethylamino)methyl)-4-phenyl-2-azetidinone 
• 4646-55-3 N,N-dimethyl-3,3-diphenylpropan-1-amine 
• 23690-05-3 (3,3-diphenyl-allyl)-dimethyl-amine 
• 69311-00-8 (3,3-diphenyl-allyl)-trimethyl-ammonium; iodide 

Relevant articles and documents

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MANUFACTURING METHOD OF β-SUBSTITUTED PROPIONIC ACID AMIDE AND N-SUBSTITUTED (METH)ACRYLAMIDE

PROBLEM TO BE SOLVED: To provide a method for industrially manufacturing β-alkoxy propionic acid amide, β-amino propionic acid amide and N-substituted (meth)acryl amide using (meth)acrylic acid ester as starting material at high yield and high purity. SOLUTION: There is provided a method for obtaining N-substituted (meth)acryl amide represented by target compound formula (7) by conducting an amidation reaction with amine using β-substituted propionic acid ester represented by the formula (1) of a product of a Michael addition reaction of (meth)acrylic acid ester and alcohol or amine in presence of a metal complex as a catalyst to obtain β-substituted propionic acid amide represented by the formula (3) and conducting a thermal decomposition reaction of β-substituted propionic acid amide in presence of the metal complex as the catalyst to eliminate alcohol or amine. A-CH2-C(R1)H-C(=O)-OR2 (1), A-CH2-C(R1)H-C(=O)-N(R3)R4 (3), CH2=C(R1)-C(=O)-N(R3)R4 (7) SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

Highly efficient procedure for the conjugate addition of amines to electron deficient alkenes

The novel efficient procedure has been developed for the conjugate addition of amines to electron deficient alkenes. The results showed that the catalyst was very efficient for the reactions with the excellent yields in several minutes. Operational simplicity, without need of any solvent, low cost of the catalyst used, high yields, reusability, excellent chemoselectivity, applicability to large-scale reactions are the key features of this methodology. The article is published in the original.