201420-30-6

Basic information

• Product Name: 4-Chloro-3-quinolinecarboxaldehyde
• Synonyms: 4-Chloro-3-quinolinecarboxaldehyde;4-chloroquinoline-3-carbaldehyde;4-chloroquinoline-3-carboxaldehyde
• CAS NO: 201420-30-6
• Molecular Formula: C₁₀H₆ClNO
• Molecular Weight: 191.616
• Mol File: 201420-30-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 162 °C(Solv: benzene (71-43-2))
• Boiling Point: 324.2 °C at 760 mmHg
• Flash Point: 149.9 °C
• Appearance: /
• Density: 1.364 g/cm³
• Vapor Pressure: 0.000249mmHg at 25°C
• Refractive Index: 1.692
• PKA: 1.93±0.24(Predicted)
• CAS DataBase Reference: 4-Chloro-3-quinolinecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3-quinolinecarboxaldehyde(201420-30-6)
• EPA Substance Registry System: 4-Chloro-3-quinolinecarboxaldehyde(201420-30-6)

Safety Data

• Hazardous Substances Data: 201420-30-6(Hazardous Substances Data)

Usage

General Description

4-Chloro-3-quinolinecarboxaldehyde, also known as quinoline-4-carboxaldehyde or 4-chloroquinoline-3-carbaldehyde, is a chemical compound with the molecular formula C10H6ClNO. It is a yellow to brown colored solid that is used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. 4-Chloro-3-quinolinecarboxaldehyde is also used as a building block for the preparation of various heterocyclic compounds, which have applications in the fields of medicine and materials science. It is mainly produced by the reaction of 3-chloroaniline with acrolein in the presence of a Lewis acid catalyst. 4-Chloro-3-quinolinecarboxaldehyde is a versatile and important chemical with a wide range of applications in the chemical industry.

InChI:InChI=1/C10H6ClNO/c11-10-7(6-13)5-12-9-4-2-1-3-8(9)10/h1-6H

Upstream product

• 551-93-9 2-aminoacetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 5234-26-4 N-(2-acetylphenyl)acetamide 
• 577-59-3 2-acetylnitrobenzene 

Downstream Products

• 7509-12-8 1,4-dihydro-4-oxoquinoline-3-carbaldehyde 
• 1257983-10-0 C₁₇H₁₁Cl₂N 
• 1257983-14-4 C₁₇H₁₁Cl₂N 
• 1257983-12-2 C₁₇H₁₁ClN₂O₂ 
• 1257983-16-6 C₁₇H₁₁ClN₂O₂ 
• 1257983-09-7 (Z)-4-chloro-3-styrylquinoline 
• 1257983-13-3 (E)-4-chloro-3-styrylquinoline 
• 1257983-11-1 (Z)-4-chloro-4'-ethoxy-3-styrylquinoline 
• 1257983-15-5 (E)-4-chloro-4'-ethoxy-3-styrylquinoline 
• 21168-46-7 4-Chlor-3-hydroxymethyl-chinolin 
• 1227000-53-4 (E)-1-methyl-3-(2-phenylvinyl)quinolin-4(1H)-one 
• 1257982-98-1 (Z)-1-methyl-3-styrylquinolin-4(1H)-one 
• 1257983-02-0 (Z)-3-styryl-1-(4-toluolsulfonyl)quinolin-4(1H)-one 
• 1257983-07-5 (E)-3-styryl-1-(4-toluolsulfonyl)quinolin-4(1H)-one 

Relevant articles and documents

Palladium-Catalyzed Synthesis of 1 H -Pyrazolo[4,3- c ]quinolines and 4-Anilinoquinoline-3-carbonitriles from 4-Chloroquinoline-3-carbaldehydes

Novel 1H-pyrazolo[4,3-c]quinolines and 4-anilinoquinoline-3-carbonitriles were prepared from readily accessible 4-chloroquinoline-3-carbaldehyde hydrazones by palladium-catalyzed intramolecular C-N bond formation and concurrent hydrazine N-N bond fission. These two classes of functionalized quinolines were chromatographically separable, and both are of biological interest. The ratio of the two products was found to be temperature-dependent; by changing the reaction temperature, either the pyrazoloquinoline or the anilinoquinolinecarbonitrile can become the dominant product.

HETEROCYCLIC COMPOUNDS AS MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)

The present invention relates to compounds of formula (I) and salts, stereoisomers, tautomers or N-oxides thereof that are useful as modulators of STING (Stimulator of Interferon Genes). The present invention further relates to the compounds of formula (I) for use as a medicament and to a pharmaceutical composition comprising said compounds.

Quinolinone compound and application thereof

The invention discloses a quinolinone compound containing rhodanine and similar fragments thereof and pharmaceutically acceptable salts thereof, and relates to the technical field of organic chemistry. The quinolinone compound is shown as general formula I in the specification, wherein substituent groups R1, X and R2 have meanings given in the specification. The invention also relates to application of the compound shown as the general formula I and the pharmaceutically acceptable salts thereof in preparing medicines for treating diseases caused by abnormal expression of IDO, in particular toapplication in preparing medicines for treating and/or preventing cancers.

MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)

The present invention relates to compounds of formula (I) and salts, stereoisomers, tautomers or N-oxides thereof that are useful as modulators of STING (Stimulator of Interferon Genes). The present invention further relates to the compounds of formula (I) for use as a medicament and to a pharmaceutical composition comprising said compounds.