2043-21-2Relevant articles and documents
P-Anisaldehyde-Photosensitized Sulfonylcyanation of Chiral Cyclobutenes: Enantioselective Access to Cyclic and Acyclic Systems Bearing All-Carbon Quaternary Stereocenters
Pirenne, Vincent,Traboulsi, Iman,Rouvière, Lisa,Lusseau, Jonathan,Massip, Stéphane,Bassani, Dario M.,Robert, Frédéric,Landais, Yannick
supporting information, p. 575 - 579 (2020/01/09)
The photosensitized p-Anisaldehyde-mediated addition of sulfonylcyanides onto the I -system of cyclobutenes is shown to afford highly functionalized cyclobutanes in high yields and diastereocontrol. The homochiral cyclobutene precursors are accessible on multigram scale in two steps through an asymmetric [2 + 2] cycloaddition/vinyl thioether reduction sequence. The enantiopure cyclobutylnitriles can be elaborated further through SmI2-mediated ring opening or converted into new enantiopure cyclobutenes through base-mediated sulfone elimination.
Ibrutinib synthesis method
-
Paragraph 0055; 0056; 0057; 0058; 0059, (2018/04/02)
The invention provides an ibrutinib synthesis method and belongs to the field of medicine synthesis. The synthesis method includes the step that a compound M and a compound of formula I undergo acylation reaction in the presence of alkaline. The synthesis method is mild in reaction conditions, side reaction is less, obtained ibrutinib is high in yield, and the purity is 99.50 or above. A syntheticroute of the synthesis method is described as follows.
Gold-catalyzed rearrangement of propargylic tert-butyl carbonates
Buzas, Andrea K.,Istrate, Florin M.,Gagosz, Fabien
experimental part, p. 1889 - 1901 (2009/06/20)
Diversely substituted 4-alkylidene-1,3-dioxolan-2-ones are efficiently synthesized by a gold(I)-catalyzed rearrangement of propargylic tert-butyl carbonates. The substrates are readily accessible and the transformation, which is performed under mild react