207223-22-1Relevant articles and documents
Enantioselective synthesis of (S)-(+)-pantolactone
Pansare, Sunil V.,Jain, Rajendra P.
, p. 175 - 177 (2007/10/03)
(equation presented) The Prins reaction of a chiral alkylidene morpholinone derived from (1R,2S)-ephedrine and 3-methyl-2-oxobutanoic acid proceeds with good diastereoselectivity to generate a spiro bis-acetal. Lewis acid mediated diastereoselective reductive cleavage of the spiro acetal and subsequent removal of the ephedrine portion generates a α-hydroxy-γ-methoxy carboxamide which is readily converted to (S)-(+)-pantolactone with high enantiomeric excess.
Asymmetric synthesis of α-alkyl-α-hydroxy-γ-butyrolactones
Pansare, Sunil V.,Jain, Rajendra P.,Ravi, R. Gnana
, p. 3103 - 3106 (2007/10/03)
A new enantioselective approach to α-alkyl-α-hydroxy-γ-butyrolactones employing (1R,2S)-ephedrine-derived chiral allyl morpholinones as starting materials is described.