207223-32-3Relevant articles and documents
Enantioselective synthesis of (S)-(+)-pantolactone
Pansare, Sunil V.,Jain, Rajendra P.
, p. 175 - 177 (2007/10/03)
(equation presented) The Prins reaction of a chiral alkylidene morpholinone derived from (1R,2S)-ephedrine and 3-methyl-2-oxobutanoic acid proceeds with good diastereoselectivity to generate a spiro bis-acetal. Lewis acid mediated diastereoselective reductive cleavage of the spiro acetal and subsequent removal of the ephedrine portion generates a α-hydroxy-γ-methoxy carboxamide which is readily converted to (S)-(+)-pantolactone with high enantiomeric excess.
Asymmetric Allylation and Reduction on an Ephedrine-Derived Template: Stereoselective Synthesis of α-Hydroxy Acids and Derivatives
Pansare, Sunil V.,Ravi, R.Gnana,Jain, Rajendra P.
, p. 4120 - 4124 (2007/10/03)
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