20725-25-1

Basic information

• Product Name: cis-4,4'-Dichlor-chalkon
• CAS NO: 20725-25-1
• Molecular Weight: 277.15
• Mol File: 20725-25-1.mol
• Article Data: 123

Chemical Properties

• CAS DataBase Reference: cis-4,4'-Dichlor-chalkon(CAS DataBase Reference)
• NIST Chemistry Reference: cis-4,4'-Dichlor-chalkon(20725-25-1)
• EPA Substance Registry System: cis-4,4'-Dichlor-chalkon(20725-25-1)

Safety Data

• Hazardous Substances Data: 20725-25-1(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 99-91-2 para-chloroacetophenone 
• 64-19-7 acetic acid 
• 19672-59-4 (E)-1,3-di(4-chlorophenyl)-2-propen-1-one 
• 67-64-1 acetone 
• 1513-29-7 (p-chlorophenyl)methanesulfonyl fluoride 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 13677-54-8 1,3-bis(4-chlorophenyl)prop-2-en-1-ol 
• 873-76-7 para-Chlorobenzyl alcohol 
• 166823-93-4 (2E)-1,3-bis(4-chlorophenyl)prop-2-en-1-ol 
• 109-77-3 malononitrile 
• 123-54-6 acetylacetone 
• 141-97-9 ethyl acetoacetate 
• 19339-59-4 1-(4-chloro-phenyl)-2-thiocyanato-ethanone 

Downstream Products

• 87275-63-6 2,3-dibromo-1,3-di(4-chlorophenyl)-1-propanone 
• 50800-82-3 3,5-bis-(4-chloro-phenyl)-4,5-dihydro-1H-pyrazole 
• 97009-36-4 1,3-Bis(4-chlorophenyl)-1-propanone 
• 20725-23-9 (2RS,3SR)-2,3-dichloro-1,3-bis-(4-chloro-phenyl)-propan-1-one 
• 20725-23-9 (2RS,3RS)-2,3-dichloro-1,3-bis-(4-chloro-phenyl)-propan-1-one 
• 13677-54-8 (+/-)-1,3t-bis-(4-chloro-phenyl)-allyl alcohol 
• 725-86-0 rac-trans-1,2-bis(4-chlorophenyl)cyclopropane 
• 57845-06-4 3-(4-chlorophenyl)-5-(4-chlorophenyl)-1-phenyl-2-pyrazoline 
• 20615-50-3 1.3-Bis-(4-chlorphenyl)-2-chlor-3-hydroxy-propanon-⁽¹⁾ 
• 20615-48-9 1.3.4.6-Tetrakis-<4-chlor-phenyl>-hexandion-(1.6) 
• 1373490-32-4 (E)-4,4'-(3-ethoxyprop-1-ene-1,3-diyl)bis(chlorobenzene) 
• 1373490-30-2 (E)-(1,3-bis(4-chlorophenyl)allyl)(propyl)sulfane 
• 1373490-31-3 (E)-2-(1,3-bis(4-chlorophenyl)allylthio)ethanol 
• 20725-25-1 1,3-bis(4-chlorophenyl)prop-2-en-1-one 

Relevant articles and documents

Novel potent and selective DPP-4 inhibitors: Design, synthesis and molecular docking study of dihydropyrimidine phthalimide hybrids

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as antihyperglycemic agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in combination with other antidiabetic drugs. Methods: A novel series of dihydropyrimidine phthalimide hybrids was synthesized and evaluated for their in vitro and in vivo DPP-4 inhibition activity and selectivity using alogliptin as reference. Oral glucose tolerance test was assessed in type 2 diabetic rats after chronic treatment with the synthesized hybrids ± metformin. Cytotoxicity and antioxidant assays were performed. Additionally, molecular docking study with DPP-4 and structure activity relationship of the novel hybrids were also studied. Results: Among the synthesized hybrids, 10g, 10i, 10e, 10d and 10b had stronger in vitro DPP-4 inhibitory activity than alogliptin. Moreover, an in vivo DPP-4 inhibition assay revealed that 10g and 10i have the strongest and the most extended blood DPP-4 inhibitory activity compared to alogliptin. In type 2 diabetic rats, hybrids 10g, 10i and 10e exhibited better glycemic control than alogliptin, an effect that further supported by metformin combination. Finally, 10j, 10e, 10h and 10d had the highest radical scavenging activity in DPPH assay. Conclusions: Hybrids 10g, 10i and 10e are potent DPP-4 inhibitors which may be beneficial for T2DM treatment.

Synthesis of lithium/cesium-Zagronas from zagrosian natural asphalt and study of their activity as novel, green, heterogeneous and homogeneous nanocatalysts in the Claisen–Schmidt and Knoevenagel condensations

A novel, heterogeneous and homogeneous basic nanocatalysts were synthesized by grafting of lithium and cesium on zagrosian natural asphalt sulfonate (Li/Cs-Zagronas). The activity of these catalysts was examined in the Claisen–Schmidt and Knoevenagel condensations under mild reaction conditions. Li/Cs-Zagronas were characterized by FT-IR spectroscopy, scanning electron microscopy, X-ray diffraction, energy-dispersive spectroscopy, inductively coupled plasma and thermogravimetric analysis techniques. These nanocatalysts were removed by simple filtration and reused several times without any deterioration of activity.

Activated charcoal-mediated synthesis of chalcones catalyzed by NaOH in water

A variety of chalcones were synthesized in good yields by the activated charcoal-mediated aldol reactions between benzaldehydes and acetophenones catalyzed by NaOH in water. 2,6-Bis((E)-benzylidene)cyclohexan-1-ones were prepared by the aldol reactions between benzaldehydes and cyclohexanone. Activated charcoal could be recycled five times without the significant decrease of yields.