21014-26-6

Basic information

• Product Name: 2-Propenoic acid, 3-cyclopropyl-, ethyl ester, (2E)-
• CAS NO: 21014-26-6
• Molecular Formula: C8H12O2
• Molecular Weight: 140.182
• Mol File: 21014-26-6.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-cyclopropyl-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-cyclopropyl-, ethyl ester, (2E)-(21014-26-6)
• EPA Substance Registry System: 2-Propenoic acid, 3-cyclopropyl-, ethyl ester, (2E)-(21014-26-6)

Safety Data

• Hazardous Substances Data: 21014-26-6(Hazardous Substances Data)

Upstream product

• 22822-85-1 ethyl sodiodiethylphosphonoacetate 
• 1489-69-6 Cyclopropanecarboxaldehyde 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 2516-33-8 Cyclopropylmethanol 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 1474-78-8 triethyl phosphonoformate 
• 17577-28-5 (ethoxycarbonylmethyl)triphenylphosphonium chloride 
• 17615-01-9 1-(triphenyl-λ⁵-phosphanylidene)pentan-2-one 
• 70398-41-3 diethyl 2-(tetrahydrofuran-2-yl)malonate 

Downstream Products

• 60129-33-1 (trans)-3-cyclopropylacrylic acid 
• 5618-03-1 3-cyclopropanepropionic acid 

Relevant articles and documents

Synthesis of α,β-unsaturated esters from dialkoxyphosphoryl esters and aldehydes in the ionic liquid [bmim][PF6]

α,β-Unsaturated esters were synthesised by LiOH·H2O-promoted reactions of triethyl phosphonoacetate 1 and triethyl 3-methyl-4-phosphono-2-butenoate 2 with aldehydes in 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]).

One-Pot Synthesis of α,β-Unsaturated Esters, Ketones, and Nitriles from Alcohols and Phosphonium Salts

A general method for the synthesis of α,β-unsaturated esters, ketones, and nitriles is successfully achieved by a one-pot copper-catalyzed oxidation with O 2 in air as oxidant. The solvent mixture of acetonitrile and formamide (1:1) is optimized to ensure the oxidation of alcohols, deprotonation of phosphonium salt, and Wittig reaction occur efficiently in one pot. A broad range of substrates has been explored for this process, including three electron-withdrawing group (CO 2 Et, COPh, CN) functionalized phosphonium salts. They reacted not only with benzylic and heteroaromatic alcohols, but also with aliphatic alcohols, forming the corresponding α,β-unsaturated esters, ketones, and nitriles in moderate to excellent yields.

ANTIVIRAL COMPOUNDS

The present invention relates to novel compounds of general formula (I) wherein the groups X, and R1 to R4 have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16.