1474-78-8 Usage
Description
Ethyl diethoxyphosphinylformate, also known as Diethyl (Ethoxycarbonyl)phosphonate, is a chemical compound that serves as an impurity in the synthesis of Foscarnet (F727400). Foscarnet is an antiviral agent that inhibits viral DNA polymerase and reverse transcriptase. Ethyl diethoxyphosphinylformate is characterized by its clear colorless to slightly yellow liquid appearance.
Uses
Used in Pharmaceutical Industry:
Ethyl diethoxyphosphinylformate is used as an intermediate in the synthesis of Foscarnet, an antiviral agent. Its role in the synthesis process is crucial for the development of Foscarnet, which is effective against various viral infections, including herpes simplex, cytomegalovirus, and human immunodeficiency virus (HIV). The compound contributes to the overall effectiveness of Foscarnet by facilitating its production and ensuring its availability for medical use.
Used in Antiviral Research:
Ethyl diethoxyphosphinylformate is also utilized in the research and development of new antiviral drugs. Its involvement in the synthesis of Foscarnet makes it a valuable compound for studying the mechanisms of action and potential applications of similar antiviral agents. This research can lead to the discovery of novel treatments for a wide range of viral diseases, ultimately benefiting public health and the medical community.
Purification Methods
Dissolve it in Et2O, shake this with H2O (to remove any trace of NaCl impurity), dry (Na2SO4), evaporate and distil it using an efficient fractionating column. [Nylén Chem Ber 57 1035 1924, Reetz et al. J Am Chem Soc 77 3813 1955, Monson Advanced Organic Synthesis Academic Press p 89 1972, Beilstein 3 II 103.]
Check Digit Verification of cas no
The CAS Registry Mumber 1474-78-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,7 and 4 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1474-78:
(6*1)+(5*4)+(4*7)+(3*4)+(2*7)+(1*8)=88
88 % 10 = 8
So 1474-78-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H15O5P/c1-4-10-7(8)13(9,11-5-2)12-6-3/h4-6H2,1-3H3