2158-01-2

Basic information

• Product Name: Urea, N-butyl-N'-cyclohexyl-
• CAS NO: 2158-01-2
• Molecular Formula: C11H22N2O
• Molecular Weight: 198.308
• Mol File: 2158-01-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Urea, N-butyl-N'-cyclohexyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-butyl-N'-cyclohexyl-(2158-01-2)
• EPA Substance Registry System: Urea, N-butyl-N'-cyclohexyl-(2158-01-2)

Safety Data

• Hazardous Substances Data: 2158-01-2(Hazardous Substances Data)

Upstream product

• 39078-72-3 S-methyl N-butylthiocarbamate 
• 108-91-8 cyclohexylamine 
• 124-38-9 carbon dioxide 
• 109-73-9 N-butylamine 
• 25070-80-8 prop-2'-en-1'-yl cyclohexylcarbamate 
• 874394-02-2 2,2,2-trichloroethyl N-cyclohexylcarbamate 
• 111-36-4 n-butyl isocyanide 
• 36323-18-9 N-Methyl-N-p-tosyl-N'-n-butylharnstoff 
• 13810-02-1 N-hydroxycyclohexanecarboxamide 
• 4630-82-4 methyl cyclohexylcarboxylate 

Downstream Products

• 116418-85-0 1-(1-butyl)-3-cyclohexylbarbituric acid 
• 827-52-1 1-phenyl-1-cyclohexane 

Relevant articles and documents

Lanthanum(III) Trifluoromethanesulfonate Catalyzed Direct Synthesis of Ureas from N-Benzyloxycarbonyl-, N -Allyloxycarbonyl-, and N -2,2,2-Trichloroethoxycarbonyl-Protected Amines

A novel lanthanum triflate mediated conversion of N -benzyloxycarbonyl-, N -allyloxycarbonyl-, and N -trichloroethoxycarbonyl-protected amines into nonsymmetric ureas was discovered. In this study, lanthanum triflate was found to be an effective catalyst for preparing various nonsymmetric ureas from protected amines. A variety of protected aromatic and aliphatic carbamates reacted readily with various amines in the presence of lanthanum triflate to generate the desired ureas in high yields. This result demonstrated that this novel lanthanum triflate catalyzed preparation of ureas from Cbz, Alloc, and Troc carbamates can be employed for the formation of various urea structures.

Synthesis of urea derivatives from amines and CO2 in the absence of catalyst and solvent

Urea derivatives are obtained in mild to good yield from the reactions of primary aliphatic amines with CO2 in the absence of any catalysts, organic solvents or other additives. To optimize reaction conditions, experimental variables including temperature, pressure, the concentration of amine, reaction time etc. were studied. Satisfactory yields were obtained at the optimized conditions that are comparable to the presence of catalyst and solvent. The preliminary investigation of the reaction mechanism showed that alkyl ammonium alkyl carbamate was quickly formed as the intermediate, and then the final product was formed by the intramolecular dehydration.

Conversion of carbonimidodithioates into unsymmetrical Di- and Tri- substituted ureas including urea dipeptides

Selective hydrolysis of carbonimidodithioates (3) leads to the thiocarbamates (4), which can be easily transformed to the unsymmetrical ureas (5) by treatmeat with the appropriate amines. This constitutes a synthesis of ureas without the use of phosgene o