217313-81-0Relevant articles and documents
Large scale preparation of protected 4-aminomethylbenzamidine. Application to the synthesis of the thrombin inhibitor, melagatran
Lila, Christine,Gloanec, Philippe,Cadet, Laurence,Herve, Yolande,Fournier, Jean,Leborgne, Fabrice,Verbeuren, Tony J.,De Nanteuil, Guillaume
, p. 4419 - 4429 (1998)
To allow the preparation of melagatran on a multigram scale, we have investigated several approaches for the synthesis of the key intermediate 4- aminomethylbenzamidine. The only industrially suitable pathway relies on the preparation of an N-hydroxyimino