222976-50-3

Basic information

• Product Name: N-[2-(4-benzyloxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-2-tert-butoxycarbonylamino-malonamic acid methyl ester
• Synonyms: N-[2-(4-benzyloxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-2-tert-butoxycarbonylamino-malonamic acid methyl ester
• CAS NO: 222976-50-3
• Molecular Weight: 586.758
• Mol File: 222976-50-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[2-(4-benzyloxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-2-tert-butoxycarbonylamino-malonamic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(4-benzyloxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-2-tert-butoxycarbonylamino-malonamic acid methyl ester(222976-50-3)
• EPA Substance Registry System: N-[2-(4-benzyloxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-2-tert-butoxycarbonylamino-malonamic acid methyl ester(222976-50-3)

Safety Data

• Hazardous Substances Data: 222976-50-3(Hazardous Substances Data)

Upstream product

• 168175-38-0 3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid 2-trimethylsilanyl-ethyl ester 
• 61172-70-1 dimethyl 2-(tert-butoxycarbonylamino)malonate 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2916-68-9 2-(Trimethylsilyl)ethanol 
• 61172-71-2 2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropanoic acid 
• 168175-39-1 (S)-2-Amino-3-(4-benzyloxy-phenyl)-propionic acid 2-trimethylsilanyl-ethyl ester 

Downstream Products

• 222976-08-1 3-(4-benzyloxy-phenyl)-2-(2-tert-butoxycarbonylamino-2-methoxycarbonyl-thioacetylamino)-propionic acid 2-trimethylsilanyl-ethyl ester 

Relevant articles and documents

Synthesis and reduction of endothiodipeptides containing malonic acid derivatives

Amides of malonic acid derivatives and protected dipeptides containing amine malonic acid have been synthesized and converted into the corresponding monothio analoga and endothiedipeptides. By reduction of the thioamides terminal protected β-carboxy amine derivatives were obtained. Reduction of endothiodipeptides containing amine malonic acid as the carboxy component resulted in protected Ψ[CH2NH] pseudodipeptides for the use as dipeptide substitutes with proteolytic resistance.