61172-70-1Relevant articles and documents
Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease
Al-Wahaibi, Lamya H.,Mostafa, Ahmed,Mostafa, Yaser A.,Abou-Ghadir, Ola F.,Abdelazeem, Ahmed H.,Gouda, Ahmed M.,Kutkat, Omnia,Abo Shama, Noura M.,Shehata, Mahmoud,Gomaa, Hesham A.M.,Abdelrahman, Mostafa H.,Mohamed, Fatma A.M.,Gu, Xuyuan,Ali, Mohamed A.,Trembleau, Laurent,Youssif, Bahaa G.M.
, (2021/09/24)
We have discovered a family of synthetic oxazole-based macrocycles to be active against SARS-CoV-2. The synthesis, pharmacological properties, and docking studies of the compounds are reported in this study. The structure of the new macrocycles was confir
Synthesis of a second-generation pseudopeptide platform
Haberhauer, Gebhard,Somogyi, László,Rebek Jr., Julius
, p. 5013 - 5016 (2007/10/03)
A synthetic pathway is presented to a functionalized pseudopeptide molecular platform for use in supramolecular and solution-phase combinatorial chemistry. The platform contains amino acids with quaternary asymmetric centers, the configurations of which are determined by the method of synthesis. (C) 2000 Elsevier Science Ltd.
Dimethyl Aminomalonate: A Useful C-3 Unit in a Mild, Direct Synthesis of Oxazole-4-carboxylates
Shapiro, Rafael
, p. 5759 - 5764 (2007/10/02)
N-Acyl derivatives of the title compound undergo oxidative cyclization upon treatment with N-chlorosuccinimide in DMF to form dimethyl 4,5-dihydro-5-(phenylthio)oxazole-4,4-dicarboxylates 4 which then are decarbomethoxylated with concomitant loss of thiop