61172-71-2

Basic information

• Product Name: 2-(tert-butoxycarbonylaMino)-3-Methoxy-3-oxopropanoic acid
• Synonyms: 2-(tert-butoxycarbonylaMino)-3-Methoxy-3-oxopropanoic acid
• CAS NO: 61172-71-2
• Molecular Formula: C₉H₁₅NO₆
• Molecular Weight: 233.2185
• Mol File: 61172-71-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(tert-butoxycarbonylaMino)-3-Methoxy-3-oxopropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(tert-butoxycarbonylaMino)-3-Methoxy-3-oxopropanoic acid(61172-71-2)
• EPA Substance Registry System: 2-(tert-butoxycarbonylaMino)-3-Methoxy-3-oxopropanoic acid(61172-71-2)

Safety Data

• Hazardous Substances Data: 61172-71-2(Hazardous Substances Data)

Usage

General Description

2-(tert-butoxycarbonylamino)-3-methoxy-3-oxopropanoic acid is a chemical compound with formula C10H17NO7. It is a derivative of propanoic acid and contains a tert-butoxycarbonyl (Boc) protecting group attached to the nitrogen atom, as well as a methoxy group and a keto group. 2-(tert-butoxycarbonylaMino)-3-Methoxy-3-oxopropanoic acid is commonly used as a reagent in organic synthesis and peptide chemistry, where the Boc protecting group can be selectively removed under mild conditions to reveal the amino group for further reactions. It is also a building block for the synthesis of various pharmaceuticals and bioactive compounds. 2-(tert-butoxycarbonylaMino)-3-Methoxy-3-oxopropanoic acid is a white to off-white solid and should be handled with care due to its potential to cause skin and eye irritation.

Upstream product

• 31954-27-5 N-(tert-butoxycarbonyl)glycine methyl ester 
• 124-38-9 carbon dioxide 
• 61172-70-1 dimethyl 2-(tert-butoxycarbonylamino)malonate 
• 4530-20-5 BOC-glycine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 146335-30-0 4,4'-dibenzyloxy-3-<(R,S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-1-oxoethyl>-3'-(1,3-dioxan-2-yl)biphenyl 
• 222976-52-5 2-tert-butoxycarbonylamino-N-[1-tert-butoxycarbonyl-2-(4-hydroxy-phenyl)-ethyl]-malonamic acid methyl ester 
• 222976-56-9 2-tert-butoxycarbonylamino-N-(1-tert-butoxycarbonyl-2-phenyl-ethyl)-malonamic acid methyl ester 
• 222976-50-3 N-[2-(4-benzyloxy-phenyl)-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-2-tert-butoxycarbonylamino-malonamic acid methyl ester 
• 218164-29-5 Boc-Ama(OMe)-Leu-OBn 
• 222976-15-0 2-(2-tert-butoxycarbonylamino-2-methoxycarbonyl-thioacetylamino)-3-phenyl-propionic acid tert-butyl ester 
• 222976-10-5 2-(2-tert-butoxycarbonylamino-2-methoxycarbonyl-thioacetylamino)-3-(4-hydroxy-phenyl)-propionic acid tert-butyl ester 
• 222976-08-1 3-(4-benzyloxy-phenyl)-2-(2-tert-butoxycarbonylamino-2-methoxycarbonyl-thioacetylamino)-propionic acid 2-trimethylsilanyl-ethyl ester 
• 143164-82-3 4,4'-dibenzyloxy-3-<(S)-2-(tert-butoxycarbonylamino)-2-methoxycarbonyl-(R)-1-hydroxyethyl>biphenyl-3'-carbaldehyde 
• 1027532-24-6 (2S,3R)-2-Amino-3-{4,4'-bis-benzyloxy-3'-[(S)-2-benzyloxycarbonylamino-2-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-biphenyl-3-yl}-3-hydroxy-propionic acid methyl ester 
• 143164-83-4 4,4'-dibenzyloxy-3-<(S)-2-(tert-butoxycarbonylamino)-2-(methoxycarbonyl)-(R)-1-hydroxyethyl>-3'-<(Z)-2-(benzyloxycarbonylamino)-2-(trimethylsilylethoxycarbonyl)vinyl>biphenyl 
• 143164-84-5 3-<(S)-2-(benzyloxycarbonylamino)-2-(trimethylsilylethoxycarbonyl)ethyl>-3'-<(S)-2-(tert-butoxycarbonylamino)-2-(methoxycarbonyl)-(R)-1-hydroxyethyl>-4,4'-dibenzyloxybiphenyl 
• 146388-29-6 (2S,3R)-2-((2S,4R)-5-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-4-hydroxy-pentanoylamino)-3-[4,4'-bis-benzyloxy-3'-((S)-2-benzyloxycarbonylamino-2-pentafluorophenyloxycarbonyl-ethyl)-biphenyl-3-yl]-3-hydroxy-propionic acid methyl ester 
• 146388-30-9 (7R,8S,11S,14S)-5,17-Bis-benzyloxy-14-benzyloxycarbonylamino-11-((R)-3-benzyloxycarbonylamino-2-hydroxy-propyl)-7-hydroxy-10,13-dioxo-9,12-diaza-tricyclo[14.3.1.1^2,6]henicosa-1⁽¹⁹⁾,2⁽²¹⁾,3,5,16⁽²⁰⁾,17-hexaene-8-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and reduction of endothiodipeptides containing malonic acid derivatives

Amides of malonic acid derivatives and protected dipeptides containing amine malonic acid have been synthesized and converted into the corresponding monothio analoga and endothiedipeptides. By reduction of the thioamides terminal protected β-carboxy amine derivatives were obtained. Reduction of endothiodipeptides containing amine malonic acid as the carboxy component resulted in protected Ψ[CH2NH] pseudodipeptides for the use as dipeptide substitutes with proteolytic resistance.

Herstellung und C-Alkylierungen von Peptiden mit Aminomalonsaeure-Bausteinen

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The aromatic amino acid constituent of echinocandin B: 3, 4-dihydroxyhomotyrosine (author's transl)

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