2246-26-6

Basic information

• Product Name: Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-1,2-dihydro-6,7-dimethoxy-2-methyl-
• Synonyms: Isoquinoline,1,2-dihydro-6,7-dimethoxy-2-methyl-1-veratryl- (7CI,8CI); 2-Methyl-1,2-dihydropapaverine;N-Methyl-1,2-dihydropapaverine; NSC 338558
• CAS NO: 2246-26-6
• Molecular Formula: C21H25 N O4
• Molecular Weight: 355.434
• Mol File: 2246-26-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-1,2-dihydro-6,7-dimethoxy-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-1,2-dihydro-6,7-dimethoxy-2-methyl-(2246-26-6)
• EPA Substance Registry System: Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-1,2-dihydro-6,7-dimethoxy-2-methyl-(2246-26-6)

Safety Data

• Hazardous Substances Data: 2246-26-6(Hazardous Substances Data)

Upstream product

• 2679-26-7 2-Methylpapaverinium iodide 
• 58-74-2 Papaverine 
• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 4673-06-7 6,7-dimethoxy-2-methyl-1-veratrylidene-1,2-dihydro-isoquinoline 

Downstream Products

• 1699-51-0 laudanosine 
• 494-99-5 1,2-dimethoxy-4-methylbenzene 
• 10548-84-2 ethoxymethyl-4 dimethoxy-1,2 benzene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 5531-95-3 N-methylpavine 
• 16620-96-5 2-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 74046-23-4 6,7-dimethoxy-2-methylisoquinolinium chloride 
• 5531-95-3 N-methylpavine 

Relevant articles and documents

Evidence for a Radical Chain Mechanism for the Knabe Reaction of 1,2-Dihydro-2-methylpapaverine

A free radical chain mechanism is proposed for the Knabe reaction and the accompanying elimination reaction on account of their nonintegral reaction order and of successful inhibition experiments. 3,4-Dimethoxybenzyl radicals are the chain carrying species.Battersby's synthesis of N-methylpavine (19) from 1,2-dihydro-2-methylpapaverine (9) is dependent on the presence of formic acid as radical chain inhibitor.In the presence of inhibitors 1-benzyl-1,4-dihydro-2-methylisoquinolinium ions like 10 are persistent species whose chemistry can now be investigated.