227609-85-0

Basic information

• Product Name: Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI)
• Synonyms: Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI);2-Fluoro-5-(hydroxymethyl)benzonitrile
• CAS NO: 227609-85-0
• Molecular Formula: C₈H₆FNO
• Molecular Weight: 151.1377432
• Product Categories: HALIDE
• Mol File: 227609-85-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 284.5 °C at 760 mmHg
• Flash Point: 125.8 °C
• Appearance: /
• Density: 1.27 g/cm³
• PKA: 13.93±0.10(Predicted)
• CAS DataBase Reference: Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI)(227609-85-0)
• EPA Substance Registry System: Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI)(227609-85-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 227609-85-0(Hazardous Substances Data)

Usage

General Description

Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI) is an organic compound with the chemical formula C8H6FNO. It is a white solid that is commonly used as a building block in the synthesis of various pharmaceutical and agricultural chemicals. Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI) is primarily used in the production of a wide range of chemicals and drugs, including anti-cancer agents and pesticides. It is also used as a reagent in the development of new drug candidates and as a starting material in the preparation of other organic compounds. Additionally, it is an important intermediate in the synthesis of various organic compounds that are used in the field of organic chemistry.

Upstream product

• 218301-22-5 2-fluoro-5-formylbenzonitrile 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 171050-06-9 3-cyano-4-fluorobenzoic acid 
• 557-21-1 zinc(II) cyanide 
• 77771-03-0 3-bromo-4-fluoro-benzyl alcohol 

Downstream Products

• 180302-35-6 5-bromomethyl-2-fluorobenzonitrile 
• 481075-38-1 2-fluoro-5-(hydroxymethyl)benzoic acid 
• 1373152-21-6 C₁₄H₂₀FNOSi 
• 1423135-12-9 tert-butyl 4-{3-[(3R)-3-{[(1S)-1-{5-[(3-cyano-4-fluorobenzyl)oxy]pyridin-3-yl}-3-methoxy-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate 

Relevant articles and documents

PYRIMIDINE DERIVATIVES AS INHIBITORS OF PD1/PD-L1 ACTIVATION

The compounds of Formula Ib, Formula Ia, and Formula I are described herein along with their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof. The process of preparation of the compounds of Formula Ib, Formula Ia, and Formula I is also described. The compounds described herein, their polymorphs, stereoisomers, tautomers, prodrugs, solvates, and pharmaceutically acceptable salts thereof are 2-(benzyloxy)pyrimidine derivatives that are inhibitors of PD-1/PD-L1 activation.

2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.

GLUCOKINASE ACTIVATORS

Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of wherein the variables are as defined herein.