227803-21-6

Basic information

• Product Name: 3-Quinolinecarboxaldehyde, 2-phenyl-
• CAS NO: 227803-21-6
• Molecular Formula: C16H11NO
• Molecular Weight: 233.269
• Mol File: 227803-21-6.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarboxaldehyde, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxaldehyde, 2-phenyl-(227803-21-6)
• EPA Substance Registry System: 3-Quinolinecarboxaldehyde, 2-phenyl-(227803-21-6)

Safety Data

• Hazardous Substances Data: 227803-21-6(Hazardous Substances Data)

Upstream product

• 103-84-4 Acetanilid 
• 2579-22-8 Phenylpropargyl aldehyde 
• 147611-21-0 N-(2-formylphenyl)-4-methoxybenzenesulfonamide 
• 151721-32-3 N-benzenesulfonyl-o-aminobenzaldehyde 
• 94532-99-7 N-(2-formylphenyl)methanesulfonamide 
• 6590-65-4 N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide 
• 271-58-9 anthranil 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 
• 98-80-6 phenylboronic acid 
• 91301-03-0 3-formyl-2-quinolone 
• 864439-58-7 3-(1,3-dioxolan-2-yl)-2-phenylquinoline 
• 529-23-7 o-aminobenzaldehyde 
• 104-55-2 3-phenyl-propenal 
• 497-19-8 sodium carbonate 

Downstream Products

• 1612190-98-3 3-phenyl-1-(2-phenylquinolin-3-yl)propan-1-one 
• 924633-18-1 C₂₄H₁₇NO₂ 
• 924633-06-7 C₂₁H₁₆N₂O 

Relevant articles and documents

Synthesis of pyrrolo[3,4-c]quinolines by 1,5-electrocyclisation of non-stabilised azomethine ylides

A new route to the pyrrolo[3,4-c]quinoline ring system has been developed via the 1,5-dipolar electrocyclisation reactions of azomethine ylides derived from easily available 3-formylquinoline derivatives. The intermediacy of azomethine ylides was shown by the trapping of the proposed dipoles with N-phenylmaleimide.

NiH-Catalyzed Hydroamination/Cyclization Cascade: Rapid Access to Quinolines

Despite the significant success of metal-H-catalyzed hydroamination methodologies, considerable limitations still exist in the selective hydroamination of alkynes, especially for terminal alkynes. Herein, we develop a highly efficient NiH catalytic system that activates readily available alkynes for a cascade hydroamination/cyclization reaction with anthranils. This mild, operationally simple protocol is amenable to a wide array of alkynes including terminal and internal, aryl and alkyl, electron-deficient and electron-rich ones, delivering structurally diverse quinolines in useful to excellent yields (>80 examples, up to 93% yield). The utility of this procedure is exhibited in the late-stage functionalization of several natural products and in the concise synthesis of an antitumor molecule graveolinine and a triplex DNA intercalator. Preliminary mechanistic experiments suggest an alkenylnickel-mediated alkyne hydroamination and an intramolecular cyclization/aromatization of putative enamine intermediates.

HETEROARYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH PI3 KINASES, CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a heteroaryl derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition for preventing or treating diseases associated with PI3 kinases, containing the same as an active ingredient. The heteroaryl derivative according to the present invention has an excellent effect of selectively inhibiting PI3 kinases, thereby being useful in preventing or treating PI3 kinase diseases such as: cancers, autoimmune diseases, and respiratory diseases.