24168-51-2Relevant articles and documents
Metal organic coordination compound and preparation method and application thereof
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Paragraph 0104-0107; 0112-0115; 0118-0121; 0124-0127, (2021/04/28)
The invention provides a metal organic coordination compound as well as a preparation method and application thereof. According to the metal organic coordination compound, the organic coordination compound with a simple structure can be prepared through two steps, namely acylating chlorination and amidation; the organic coordination compound can be used for preparing an organic coordination compound of a conductive conjugated polymer; an experimental scheme is simple and convenient, and raw materials are cheap and widely available; and besides preparation of coordination compounds containing thiophene groups, the method can be expanded to synthesis of coordination compounds containing pyrrole groups, fluorene groups and the like.
Structure–Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers
Teodori, Elisabetta,Dei, Silvia,Bartolucci, Gianluca,Perrone, Maria Grazia,Manetti, Dina,Romanelli, Maria Novella,Contino, Marialessandra,Colabufo, Nicola Antonio
, p. 1369 - 1379 (2017/09/01)
A series of derivatives were synthesized and studied with the aim to investigate the structure–activity relationships of the two P-glycoprotein (P-gp) modulators elacridar and tariquidar. Then, different aryl-substituted amides were inserted, and to explore the effects of varying the amide function, the corresponding isosteric ester derivatives and some alkylamine analogues were synthesized. The new compounds were studied to evaluate their P-gp interaction profile and selectivity toward the two other ABC transporters, multidrug-resistance-associated protein-1 (MRP-1) and breast cancer resistance protein (BCRP). Investigation of the chemical stability of the amide and ester derivatives toward spontaneous or enzymatic hydrolysis showed that these compounds were stable in phosphate-buffered saline and human plasma. This study allowed us to evaluate the selectivity of the three series on the three efflux pumps and to propose the structural requirements that define the P-gp interaction profile. We identified two P-gp substrates, a P-gp inhibitor, and three ester derivatives that were active on BCRP, which opens a new scenario in the development of ligands active toward this pump.
Orally active esters of dihydroartemisinin: Synthesis and antimalarial activity against multidrug-resistant Plasmodium yoelii in mice
Singh, Chandan,Chaudhary, Sandeep,Puri, Sunil K.
, p. 1436 - 1441 (2008/09/19)
A series of artemisinin derived esters 7a-j, incorporating pharmacologically privileged substructure, such as biphenyl, adamantane and fluorene, have been prepared and evaluated for antimalarial activity against multidrug-resistant (MDR) Plasmodium yoelii
