247133-22-8

Basic information

• Product Name: 8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE
• Synonyms: 8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE;8-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepine
• CAS NO: 247133-22-8
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 247133-22-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 297.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.018±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.89±0.20(Predicted)
• CAS DataBase Reference: 8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE(247133-22-8)
• EPA Substance Registry System: 8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE(247133-22-8)

Safety Data

• Hazardous Substances Data: 247133-22-8(Hazardous Substances Data)

Usage

General Description

8-METHOXY-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE, also known as lefetamine, is a chemical compound belonging to the family of benzazepines. It is a psychoactive substance that acts as a selective agonist for the dopamine D2 and D3 receptors. Lefetamine has been studied for its potential use in the treatment of various psychological and neurological disorders, including depression and Parkinson's disease. It has also been used as a recreational drug due to its stimulant and hallucinogenic effects. Lefetamine has been banned in several countries due to its potential for abuse and adverse health effects.

Upstream product

• 341548-14-9 2-formyl-8-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepine 
• 22246-71-5 8-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepin-1-one 
• 591-31-1 3-methoxy-benzaldehyde 
• 341547-88-4 N-(3-methoxyphenyl)methyl-(3-phenylsulfanyl)propylamine 
• 341547-95-3 N-(3-methoxyphenyl)methyl-N-[(3-phenylsulfanyl)propyl]formamide 
• 341548-07-0 2-formyl-8-methoxy-5-phenylsulfanyl-2,3,4,5-tetrahydro-1H-2-benzazepine 
• 341548-01-4 N-(3-methoxyphenyl)methyl-N-[(3-phenylsulfinyl)propyl]formamide 
• 4133-34-0 7-methoxyl-2-tetralone 

Downstream Products

• 374813-35-1 2,3,4,5-tetrahydro-1H-2-benzazepin-8-ol hydrobromide 
• 247133-24-0 8-hydroxy-2,3,4,5-tetrahydro-1H-benz[c]azepine-2-carboxylic acid tert-butyl ester 
• 355395-74-3 2-[(4-fluorophenyl)methyl]-8-[3-(4-piperidinyl)propoxy]-2,3,4,5-tetrahydro-1H-2-benzazepine 

Relevant articles and documents

Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists

We describe the discovery of small molecule benzazepine derivatives as agonists of human peroxisome proliferator-activated receptor δ (PPARδ) that displayed excellent selectivity over the PPARα and PPARγ subtypes. Compound 8 displayed good PK in the rat a

Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring

A series of novel 2,7-disubstituted tetrahydroisoquinoline derivatives were designed and synthesized. Among these derivatives, compounds 1 and 2 exhibited potent inhibitory activity against factor Xa (FXa) and good selectivity with respect to other serine

NITROGENOUS FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME

A nitrogen-containing condensed heterocyclic derivative of the present invention, which is a compound represented by the formula: wherein ring A represents benzene ring optionally having a further substituent, -L-represents -O-, -NR3a-, -S-, -SO-, -SO2-, -SO2NR3a-, -SO2NHCONR3a-, -SO2NHC(=NH)NR3a-, -C(=S)-, or -CONR3a- (wherein R3a and R3b represent independently hydrogen atom, cyano group, hydroxy group, amino group, a C1-6 alkyl group or a C1-6 alkoxy group), n represents an integer of 0 to 6, R is hydrogen atom or a hydrocarbon group optionally having a substituent, and may be different in repetition of n, R1 represents a hydrocarbon group optionally having a substituent or a group represented by the formula: (wherein R7 represents a hydrocarbon group optionally having a substituent), R2 represents hydrogen atom, an acyl group, a hydrocarbon group optionally having a substituent or a heterocyclic group optionally having a substituent, X represents a bond, O, S, SO, SO2 or NR4 (wherein R4 represents hydrogen atom, an acyl group or a hydrocarbon group optionally having a substituent), k and m represent independently an integer of 0 to 5, and 1k+m5, or a salt thereof, and the like, has an excellent thermal production promoting activity and the like, and is useful as an agent for preventing or treating obesity and obesity-based diseases.