247133-24-0

Basic information

• Product Name: TERT-BUTYL 8-HYDROXY-4,5-DIHYDRO-1H-BENZO[C]AZEPINE-2(3H)-CARBOXYLATE
• Synonyms: TERT-BUTYL 8-HYDROXY-4,5-DIHYDRO-1H-BENZO[C]AZEPINE-2(3H)-CARBOXYLATE;tert-butyl 8-hydroxy-2,3,4,5-tetrahydro-1H-2-benzazepine-2-carboxylate;tert-Butyl 8-hydroxy-1,3,4,5-tetrahydro-2H-benzo[c]azepine-2-carboxylate
• CAS NO: 247133-24-0
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.33
• Mol File: 247133-24-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 405.955°C at 760 mmHg
• Flash Point: 199.314°C
• Appearance: /
• Density: 1.142g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: 2-8°C
• PKA: 10.22±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL 8-HYDROXY-4,5-DIHYDRO-1H-BENZO[C]AZEPINE-2(3H)-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 8-HYDROXY-4,5-DIHYDRO-1H-BENZO[C]AZEPINE-2(3H)-CARBOXYLATE(247133-24-0)
• EPA Substance Registry System: TERT-BUTYL 8-HYDROXY-4,5-DIHYDRO-1H-BENZO[C]AZEPINE-2(3H)-CARBOXYLATE(247133-24-0)

Safety Data

• Hazardous Substances Data: 247133-24-0(Hazardous Substances Data)

Usage

General Description

Tert-butyl 8-hydroxy-4,5-dihydro-1H-benzo[c]azepine-2(3H)-carboxylate is a chemical compound that belongs to the class of organic compounds known as hydroxybenzoic acid esters. It is a synthetic compound with a molecular formula of C19H23NO3 and a molecular weight of 313.39 g/mol. This chemical is a carboxylate ester, which means it contains a carbonyl group attached to an alkyl group, and a hydroxyl group attached to a benzene ring. Tert-butyl 8-hydroxy-4,5-dihydro-1H-benzo[c]azepine-2(3H)-carboxylate may be used in pharmaceutical research and drug development due to its potential biological activities. However, it is important to use this compound with caution and follow proper safety protocols due to its potential hazards.

InChI:InChI=1/C15H21NO3/c1-15(2,3)19-14(18)16-8-4-5-11-6-7-13(17)9-12(11)10-16/h6-7,9,17H,4-5,8,10H2,1-3H3

Upstream product

• 374813-35-1 2,3,4,5-tetrahydro-1H-2-benzazepin-8-ol hydrobromide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 22246-71-5 8-methoxy-2,3,4,5-tetrahydro-1H-2-benzazepin-1-one 
• 247133-22-8 8-Methoxy-2,3,4,5-tetrahydro-1H-benz[c]azepine 
• 188576-49-0 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester 
• 4133-34-0 7-methoxyl-2-tetralone 

Downstream Products

• 374812-79-0 tert-Butyl 8-[3-[4-(4-chlorophenyl)-1-piperidinyl] propoxy]-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carboxylate 

Relevant articles and documents

Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists

We describe the discovery of small molecule benzazepine derivatives as agonists of human peroxisome proliferator-activated receptor δ (PPARδ) that displayed excellent selectivity over the PPARα and PPARγ subtypes. Compound 8 displayed good PK in the rat a

Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring

A series of novel 2,7-disubstituted tetrahydroisoquinoline derivatives were designed and synthesized. Among these derivatives, compounds 1 and 2 exhibited potent inhibitory activity against factor Xa (FXa) and good selectivity with respect to other serine

Melanin-concentrating hormone antagonist

A melanin-concentrating hormone antagonist comprising a compound of the formula: wherein R is hydrogen atom or a cyclic group which may be substituted; X is a bond or a spacer having a main chain of 1 to 10 atoms; Y is a spacer having a main chain of 1 to 6 atoms; ring A is benzene ring which may be further substituted; ring B is a 5- to 9-membered nitrogen-containing non-aromatic heterocyclic ring which may be further substituted; R1 and R2 are the same or different and are hydrogen atom, a hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; or R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic ring which may be substituted; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing heterocyclic ring which may be substituted; or a salt thereof is useful as a preventive or therapeutic agent for obesity, etc.