2484-60-8Relevant articles and documents
Photocatalyzed, β-Selective Hydrocarboxylation of α,β-Unsaturated Esters with CO2under Flow for β-Lactone Synthesis
Kang, Guowei,Romo, Daniel
, p. 1309 - 1315 (2021/02/01)
A photocatalyzed, β-selective hydrocarboxylation of α,β-unsaturated esters employing CO2 radical anion generated under flow conditions was developed. A range of substrates bearing a variety of functional groups were tolerated, demonstrating chemoselectivity. A series of quaternary carboxylic acids were obtained from sterically demanding β,β-disubstituted alkenes including those derived from natural products. Mechanistic studies support a Giese-type CO2 radical anion conjugate addition followed by hydrogen atom transfer from (TMS)3SiH as the principal reaction pathway. Finally, a telescoped process involving the described β-carboxylation followed by a α-bromination/β-lactonization sequence provides a strategy for β-lactone synthesis.
Synthesis of trans-fused octahydroisoindole-1-carboxylic acids
Laborda, Pedro,Sayago, Francisco J.,Cativiela, Carlos,Gotor, Vicente
, p. 404 - 411 (2018/05/22)
trans-Fused octahydroisoindole-1-carboxylic acids are bicyclic proline analogues of potential interest in the search for new drugs. Within this work, the trans-fused octahydroisoindole system has been constructed using methyl trans-2-(hydroxymethyl)cycloh
PROCESS OF MAKING PROSTACYCLIN COMPOUNDS WITH LINKER THIOL AND PEGYLATED FORMS
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Paragraph 197; 198, (2014/09/30)
A process provides for producing chiral prostacyclin derivatives of Formula (I) in high yield from meso anhydrides.
