25705-52-6Relevant articles and documents
Axially chiral dicarboxylic acid-catalyzed asymmetric imino aza-enamine reaction/oxidation as a Strecker reaction surrogate
Hashimoto, Takuya,Kimura, Hidenori,Maruoka, Keiji
experimental part, p. 1187 - 1188 (2010/11/02)
Axially chiral dicarboxylic acid-catalyzed highly enantioselective imino aza-enamine reaction was elaborated into a surrogate of the asymmetric Strecker reaction building on the fact that the N,N-dialkylhydrazone moiety can be easily converted to the cyanide moiety by treatment with peracid.
Asymmetric allylboration of α,β-enals as a surrogate for the enantioselective synthesis of allylic amines and α-amino acids
Ramachandran, P. Veeraraghavan,Burghardt, Thomas E.,Reddy, M. Venkat Ram
, p. 2329 - 2331 (2007/10/03)
(Chemical Equation Presented) Optically pure allylic amines have been synthesized from α,β-unsaturated aldehydes via allylboration with (-)-B-allyldiisopinocampheylborane, followed by Overman rearrangement. By incorporating crotyl and alkoxyallylboration, functionalization at δ-position was readily accomplished. By applying this methodology, the synthesis of several chiral α-amino acids has been achieved.
Synthesis of chiral α-amino acids
Chakraborty, Tushar K.,Ghosh, Animesh
, p. 9691 - 9693 (2007/10/03)
A novel method for the synthesis of chiral α-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the α-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction.