259794-53-1

Basic information

• Product Name: tert-Butyl 3-amino-2,2-dimethylpropanoate
• Synonyms: tert-Butyl 3-amino-2,2-dimethylpropanoate
• CAS NO: 259794-53-1
• Molecular Formula: C₉H₁₉NO₂
• Molecular Weight: 173.25266
• Mol File: 259794-53-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 221.7±23.0 °C(Predicted)
• Appearance: /
• Density: 0.939±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.75±0.10(Predicted)
• CAS DataBase Reference: tert-Butyl 3-amino-2,2-dimethylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 3-amino-2,2-dimethylpropanoate(259794-53-1)
• EPA Substance Registry System: tert-Butyl 3-amino-2,2-dimethylpropanoate(259794-53-1)

Safety Data

• Hazardous Substances Data: 259794-53-1(Hazardous Substances Data)

Usage

Description

Tert-Butyl 3-amino-2,2-dimethylpropanoate is an organic compound with the molecular formula C8H15NO2. It is a derivative of amino acids and has a unique structure that makes it potentially useful in various applications.

Uses

Used in Pharmaceutical Industry:
Tert-Butyl 3-amino-2,2-dimethylpropanoate is used as an active pharmaceutical ingredient for the treatment of Hepatitis B Virus (HBV) infection or HBV-induced diseases. Its unique structure allows it to target and combat the virus effectively, providing a potential therapeutic option for patients suffering from HBV-related conditions.

Upstream product

• 259794-52-0 tert-butyl 3-{[(benzyloxy)carbonyl]amino}-2,2-dimethylpropanoate 
• 19036-43-2 aminopivalic acid 
• 14002-80-3 Methyl 2,2-dimethyl-3-hydroxypropionate 
• 80253-36-7 3-(benzyloxycarbonylamino)-2,2-dimethylpropanoic acid 
• 259794-51-9 methyl 2,2-dimethyl-3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoate 
• 75235-66-4 cyano-dimethylacetic acid tert-butyl ester 

Downstream Products

• 259794-60-0 (+/-)-methyl 2-[({[2-(tert-butoxycarbonyl)-2,2-dimethylethyl]amino}sulfonyl)amino]-4-phenylbutanoate 
• 259794-64-4 (+/-)-tert-butyl 2,2-dimethyl-3-[4-(2-phenylethyl)-1,1,3-trioxo-1λ⁶,2,5-thiadiazolan-2-yl]propanoate 
• 1455091-72-1 3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester 
• 1455087-31-6 3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester 
• 1455091-78-7 3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester 
• 1455087-34-9 3-{[7-(4-chloro-3-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid 
• 1455092-29-1 3-{[7-(2-chloro-5-fluorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester 
• 1455087-53-2 3-{[7-(2-chloro-5-fluorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid 
• 1455093-66-9 3-{[7-(2-chloro-4-fluorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid tert-butyl ester 
• 1455089-03-8 3-{[7-(2-chloro-4-fluorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid 
• 1455089-06-1 3-{[1-cyano-7-(4-fluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethylpropionic acid 
• 1455094-67-3 3-[(1-cyano-7-cyclohexyloxy-4-hydroxy-isoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid tert-butyl ester 
• 1455090-36-4 3-[(1-cyano-7-cyclohexanesulfonyl-4-hydroxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid 
• 1455090-28-4 3-[(1-cyano-7-cyclohexyloxy-4-hydroxy-isoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid 

Relevant articles and documents

AMINOPYRAZOLONE DERIVATIVE

The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which has an excellent inhibitory action on the ATPase activity of a TIP48/TIP49 complex and as such, is useful for the treatment of tumors. [Solution] The present invention provides a compound having a structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the present specification.

Synthesis of 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives and evaluation of their affinity for MHC class-II proteins

1,2,5-Thiadiazolidin-3-one 1,1-dioxide derivatives (±)-1a-d and (±)-2 were designed by molecular modeling as MHC (major histocompatibility complex) class-II inhibitors. They were prepared from the unsymmetrically N,N'- disubstituted acyclic sulfamides (±)