2719-26-8

Basic information

• Product Name: Cyclohexanecarboxamide, N-phenyl-
• Synonyms: Cyclohexanecarboxamide, N-phenyl-
• CAS NO: 2719-26-8
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.28
• Mol File: 2719-26-8.mol
• Article Data: 98

Chemical Properties

• Boiling Point: 387.3°Cat760mmHg
• Flash Point: 232.2°C
• Appearance: /
• Density: 1.098g/cm³
• Vapor Pressure: 3.32E-06mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: Cyclohexanecarboxamide, N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxamide, N-phenyl-(2719-26-8)
• EPA Substance Registry System: Cyclohexanecarboxamide, N-phenyl-(2719-26-8)

Safety Data

• Hazardous Substances Data: 2719-26-8(Hazardous Substances Data)

Usage

General Description

Cyclohexanecarboxamide, N-phenyl- is a chemical compound that belongs to the amide group. It is also known as N-phenylcyclohexanecarboxamide and is commonly used as an intermediate in the production of various pharmaceuticals and agrochemicals. It is a white solid with a molecular formula of C13H17NO and a molecular weight of 203.28 g/mol. This chemical is also used as a building block in the synthesis of other organic compounds and has applications in the field of organic synthesis and chemical research. It is important to handle this compound with care and follow safety guidelines due to its potential hazards and risks.

InChI:InChI=1/C13H17NO/c15-13(11-7-3-1-4-8-11)14-12-9-5-2-6-10-12/h2,5-6,9-11H,1,3-4,7-8H2,(H,14,15)

Upstream product

• 23517-35-3 (Z)-cyclohexyl(phenyl)methanone oxime 
• 931-51-1 cyclohexylmagnesiumchloride 
• 103-71-9 phenyl isocyanate 
• 931-50-0 cyclohexylmagnesium bromide 
• 62-53-3 aniline 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 2043-61-0 cyclohexanecarbaldehyde 
• 98-89-5 Cyclohexanecarboxylic acid 
• 4904-55-6 cyclohexanecarbonyl peroxide 
• 101617-15-6 dicyclohexylammonium cyclohexanecarboxylate 
• 57-11-4 stearic acid 
• 60718-45-8 1-cyclohexanecarbonyl-1H-imidazole 
• 538-75-0 dicyclohexyl-carbodiimide 
• 3743-70-2 N-(2-hydroxyphenyl)benzamide 

Downstream Products

• 101090-33-9 2-cyclohexyLiDene-3-phenyl-oxazolidine-4,5-dione 
• 4664-67-9 <1-Chlor-cyclohexyl>-<4-dimethylamino-phenyl>-keton 
• 4664-73-7 1-Chlor-cyclohexan-1-carbonsaeure-anilid 
• 6064-01-3 Cyclohexanecarbonyl-phenyl-carbamic acid isopropyl ester 
• 1613-43-0 2-cyclohexylquinoline 
• 106989-85-9 2-phenyl-2-aza-spiro[4.5]decane-1,3,4-trione 
• 1262796-62-2 C₂₃H₂₃NO 
• 1354550-00-7 difluoromethyl N-phenyl-1-cyclohexylmethanimidate 
• 1360571-16-9 2,4-dichlorophenyl N-phenylcyclohexanecarboximidate 
• 91790-88-4 C₁₉H₂₂N₂ 
• 53300-46-2 N-(cyclohexylthiocarbonyl)aniline 
• 128815-38-3 N,N-diphenylcyclohexanecarboxamide 

Relevant articles and documents

Copper-Catalyzed Carbonylative Coupling of Cycloalkanes and Amides

Carbonylation reactions are a most powerful method for the synthesis of carbonyl-containing compounds. However, most known carbonylation procedures still require noble-metal catalysts and the use of activated compounds and good nucleophiles as substrates.

Preparation method of amide

The invention relates to a preparation method of an amide, wherein, under the action of oxygen, the isothiocyanate and the aldehyde can react to form an amide, and the reaction temperature can be effectively increased only when not less than 110 °C. This process is also suitable for the reaction of isocyanates with aldehydes to produce amides. The preparation method is cheap in raw material, wide in substrate application range and free of metal catalysts in the reaction process. The initiator or other activator is green and economical, and can effectively reduce the cost.

Beckmann rearrangement of ketoximes promoted by cyanuric chloride and dimethyl sulfoxide under a mild condition

Synthesis of amides via Beckmann rearrangement of ketoximes promoted by cyanuric chloride (TCT)/DMSO under mild conditions has been reported. Conditions of the Beckmann rearrangement, e.g., solvents, the ratios of TCT/DMSO, and the temperature, were investigated using diphenylmethanone oxime as a substrate. The optimized conditions were adopted to afford fourteen amides with yields ranging from 20% to 99%. A plausible mechanism involving an active dimethyl alkoxysulfonium intermediate was proposed according to the mass spectrometry analysis. To our best knowledge, this is the first case of study on Beckmann rearrangement of ketoximes promoted by TCT/DMSO under a mild condition to afford amides efficiently.