28078-88-8

Basic information

• Product Name: Phenol, pentafluoro-, 4-nitrobenzoate
• CAS NO: 28078-88-8
• Molecular Formula: C13H4F5NO4
• Molecular Weight: 333.171
• Mol File: 28078-88-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phenol, pentafluoro-, 4-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, pentafluoro-, 4-nitrobenzoate(28078-88-8)
• EPA Substance Registry System: Phenol, pentafluoro-, 4-nitrobenzoate(28078-88-8)

Safety Data

• Hazardous Substances Data: 28078-88-8(Hazardous Substances Data)

Upstream product

• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 62-23-7 4-nitro-benzoic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 188837-53-8 (2,3,4,5,6-pentafluorophenyl)pyridine-2-carboxylate 

Downstream Products

• 4402-22-6 N,N'-bis-(4-nitro-benzoyl)-hydrazine 
• 1429-05-6 phenyl 4-nitrobenzoate 
• 38909-96-5 N-ethyl-4-nitro-N-phenylbenzamide 

Relevant articles and documents

Hydrogen peroxide responsive polymer nano-carrier with fluorescence ratio characteristic as well as preparation method and application thereof

The invention relates to a hydrogen peroxide responsive polymer nano-carrier with a fluorescence ratio characteristic. The nano-carrier is of a spherical micelle structure, and is formed by self-assembling of an amphiphilic block copolymer with hydrogen peroxide responsiveness and ratiometric fluorescence imaging characteristics. The structural formula of the amphiphilic block copolymer having hydrogen peroxide responsiveness and ratiometric fluorescence imaging characteristics is as follows: R1 is a group having hydrogen peroxide responsiveness; R2 is a group with an aggregation-induced emission effect; R3 is a PEG hydrophilic chain; and R5 is a group with strong positive charges. The nano-carrier disclosed by the invention can be used for loading, transporting and program releasing of hydrophobic dye molecules and drug molecules as well as cell imaging and fluorescent molecular probes.

Aminolysis of aryl ester using tertiary amine as amino donor via c-o and c-n bond activations

An aminolysis reaction between various aryl esters and inert tertiary amines by C-O and C-N bond activations has been developed for the selective synthesis of a broad scope of tertiary amides under neutral and mild conditions. The mechanism may undergo the two key steps of oxidative addition of acyl C-O bond in parent ester and C-N bond cleavage of tertiary amine via an iminium-type intermediate.

Pentafluorophenyl ester activation for the preparation of N,N'-diaroylhydrazines

Procedures are reported for the preparation of N,N'-diaroylhydrazines using pentafluorophenyl (Pfp) ester activation of aryl carboxylic acids. Mild conditions which avoid intermediate protection of ring substituents, allows the synthesis of both symmetrical and unsymmetrical diaroylhydrazines in high yields. The recent discovery of potent HIV-1 integrase inhibition by N,N'-bis-salicylhydrazine (1) highlights the potential importance of this class of compounds. The stability of pre-activated Pfp ester intermediates and the facility with which N,N'-diaroylhydrazines can be synthesized using this procedure (stirring at room temperature in DMF) may make the method particularly attractive for synthesis of hydrazide libraries.