287717-44-6

Basic information

• Product Name: [(1R,4S)-4-Aminocyclopent-2-enyl]methanol hydrochloride
• Synonyms: (1R,4S)-4-Aminocyclopentene-1-methanol hydrochloride;[(1R,4S)-4-Aminocyclopent-2-enyl]methanol hydrochloride;(1S,4R)-4-aminocyclopent-2-enyl)methanol hydrochloride;(1R,4S)-4-amino-2-Cyclopentene-1-methanol hydrochloride;[(1R,4S)-4-Aminocyclopent-2-enyl]methanol;((1R,4S)-4-Aminocyclopent-2-en-1-yl)methanol hydrochloride
• CAS NO: 287717-44-6
• Molecular Formula: C6H12ClNO
• Molecular Weight: 149.62
• Mol File: 287717-44-6.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: [(1R,4S)-4-Aminocyclopent-2-enyl]methanol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: [(1R,4S)-4-Aminocyclopent-2-enyl]methanol hydrochloride(287717-44-6)
• EPA Substance Registry System: [(1R,4S)-4-Aminocyclopent-2-enyl]methanol hydrochloride(287717-44-6)

Safety Data

• Hazardous Substances Data: 287717-44-6(Hazardous Substances Data)

Usage

Description

[(1R,4S)-4-Aminocyclopent-2-enyl]methanol hydrochloride is an organic compound with a unique structure, characterized by its cyclopentane ring and amino group. It is a derivative of cyclopent-2-enylmethanol, where the hydroxyl group is substituted with an amino group at the 4-position, and the compound is in its hydrochloride salt form.

Uses

Used in Pharmaceutical Industry:
[(1R,4S)-4-Aminocyclopent-2-enyl]methanol hydrochloride is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly for the preparation of functionalized cyclic and bicyclic N-arylamines. Its unique structure allows for the exploration of novel chemical reactions and the development of new drug candidates with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, [(1R,4S)-4-Aminocyclopent-2-enyl]methanol hydrochloride serves as a valuable compound for investigating the scope of unexpected Mitsunobu cyclization reactions. This research can lead to the discovery of new synthetic methods and the development of more efficient processes for the preparation of complex organic molecules.

InChI:InChI=1/C6H11NO.ClH/c7-6-2-1-5(3-6)4-8;/h1,6,8H,2-4,7H2;1H/t6-;/m0./s1

Upstream product

• 419563-22-7 (1S,4R)-methyl 4-aminocyclopent-2-enecarboxylate L-hydrogen tartrate 
• 216481-83-3 (+)-(1S,4R)-tert-butyl N-[4-(hydroxymethyl)-2-cyclopenten-1-yl]carbamate 
• 153011-43-9 (1S,cis)-tert-butyl N-[4-(hydroxymethyl)-2-cyclopenten-1-yl]carbamate 
• 229613-86-9 (1S,4R)-(-)ethyl-4-aminocyclopent-2-ene-1-carboxylate hydrochloride 
• 168960-18-7 (1R,4S)-N-(tert-Butyloxycarbonyl)-1-amino-4-(hydroxymethyl)-2-cyclopentene 
• 168773-65-7 (1R,4S)-1-<(tert-Butyloxycarbonyl)amino>-4-(hydroxymethyl)-2-cyclopentene 
• 172720-97-7 (+/-)-tert-butyl (1RS,4SR)-4-(hydroxymethyl)cyclopent-2-enylcarbamate 
• 49805-30-3 2-azabicyclo[2.2.1.]hept-5-en-3-one 
• 61865-62-1 cis-4-aminocyclopent-2-nene-1-carboxylic acid hydrochloride 
• 76909-91-6 rel-(1R,5R)-5-(hydroxymethyl)cyclopent-2-en-1-ol 
• 77745-25-6 cis-4-amino-2-cyclopentenecarboxylic acid methyl ester hydrochloride 
• 77745-26-7 Methyl trans-4-Aminocyclopent-2-enecarboxylate Hydrochloride 

Downstream Products

• 896716-96-4 4-[(2',5'-diamino-6'-chloropyrimidin-4'-yl)-amino]cyclopent-2-enylmethanol 
• 199395-81-8 (1R,4S)-N-butyryl-1-amino-4-(hydroxymethyl)-2-cyclopentene 
• 199395-81-8 (1S,4R)-N-butyryl-1-amino-4-(hydroxymethyl)-2-cyclopentene 
• 171887-04-0 (1R,4S)-1-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-4-(hydroxymethyl)-2-cyclopentene 
• 141271-12-7 (1S, 4R)-(4-(2,5-diamino-6-chloro-4-pyrimidinyl)amino)-2-cyclopenten-1-methanol 
• 112966-73-1 [(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methanol 
• 918492-98-5 (1α,4α)-4-(6-Chloro-9H-purin-9-yl)-2-cyclopentenyl-carbinol 
• 220285-03-0 [(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methanol 
• 158799-91-8 (1R,cis)-4-(6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol 
• 168960-18-7 (1R,4S)-N-(tert-Butyloxycarbonyl)-1-amino-4-(hydroxymethyl)-2-cyclopentene 
• 61865-50-7 (+/-)-(1RS,4SR)acetic acid 4-acetylamido-cyclopent-2-enyl-methyl ester 
• 77745-30-3 trans-4-Acetamidocyclopent-2-enemethyl Acetate 

Relevant articles and documents

An expedient synthesis of oxazepino and oxazocino quinazolines

A synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring is reported. An expedient synthetic route involving nucleophilic aromatic substitution, and sequential Niementowski and BOP-mediated ring clos

A Mitsunobu reaction to functionalized cyclic and bicyclic N-arylamines

The scope of an unexpected Mitsunobu cyclisation to prepare N-arylated Fsp3-enriched azacycles was investigated. In the current study, we have identified whether a pKa-dependent Mitsunobu cyclodehydration or a pKa-independent Mitsunobu intramolecular reaction was in operation. A Mitsunobu reaction, creating a leaving group, followed by intramolecular nucleophilic displacement was determined to be the dominant pathway.

PROCESS FOR THE PREPARATION OF AMINO ALCOHOL DERIVATIVES OR SALTS THEREOF

The present invention relates to a process for the preparation of amino alcohol derivatives or salts thereof. In particular the present invention relates to process for the preparation of amino alcohol derivatives or salts thereof which may be used as intermediates in the preparation of HIV reverse transcriptase inhibitors, more preferably Carbovir and Abacavir. The present invention more specifically relates to a process for the preparation of (1S,4R)-4-amino-2-cyclopentene-1-methanol of Formula IIIa. The present invention also specifically relates to process for the preparation of Abacavir sulfate of Formula II using compound of Formula IIIa prepared according to the process of the present invention.