288250-47-5 Usage
Description
Y320, also known as 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide, is an orally active immunomodulator that inhibits IL-17 production by CD4 T cells stimulated with IL-15 with an IC50 of 20 to 60 nM. It has been shown to inhibit T cell activation induced by IL-15 and exhibits a therapeutic effect on collagen-induced arthritis in DBA/1J mice.
Uses
Used in Pharmaceutical Industry:
Y320 is used as an immunomodulator for its ability to inhibit IL-17 production by CD4 T cells stimulated with IL-15, making it a potential candidate for the treatment of autoimmune diseases and inflammatory conditions.
Used in Autoimmune Disease Treatment:
Y320 is used as a therapeutic agent for its ability to inhibit T cell activation induced by IL-15, which can help in managing the symptoms and progression of autoimmune diseases such as collagen-induced arthritis in DBA/1J mice.
Used in Inflammatory Conditions Management:
Y320 is used as an anti-inflammatory agent for its potential to modulate the immune response and reduce inflammation in various inflammatory conditions.
In vitro
Y-320 also inhibits the production of IFN-γ and TNF-α by mouse CD4 T cells stimulated with IL-15, CXCL12, and anti-CD3 mAb.
In vivo
Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice.
Biological Activity
y-320 is a new phenylpyrazoleanilide immunomodulator [1].immunotherapy refers to treatment of disease by suppressing, inducing or enhancing an immune response.y-320 is a new phenylpyrazoleanilide immunomodulator. y-320 inhibited il-17 production by cd4 t cells induced by il-15 with ic50 values of 20-60 nm [1].in type ii collagen-induced arthritis (cia) mice, oral administration of y-320 (0.3-3 mg/kg) reduced il-17 mrna expression and significantly inhibited the development of joint destruction and arthritis. the combination of y-320 with anti-murine tumor necrosis factor-α (tnf-α) monoclonal antibody exhibited a synergistic effect. in cynomolgus monkeys, y-320 (0.3-1 mg/kg) relieved cia. these results suggested that y-320 could be a useful candidate for therapy of rheumatoid arthritis (ra) [1].
references
[1]. ushio h, ishibuchi s, oshita k, et al. a new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. pharmaceuticals (basel), 2013, 7(1): 1-17.
Check Digit Verification of cas no
The CAS Registry Mumber 288250-47-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,8,2,5 and 0 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 288250-47:
(8*2)+(7*8)+(6*8)+(5*2)+(4*5)+(3*0)+(2*4)+(1*7)=165
165 % 10 = 5
So 288250-47-5 is a valid CAS Registry Number.
288250-47-5Relevant articles and documents
AMIDE COMPOUNDS AND MEDICINAL USE THEREOF
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, (2010/01/31)
The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.
