294181-95-6

Basic information

• Product Name: ethyl 2-(5-bromopyridin-2-yl)-2,2-difluoroacetate
• Synonyms: ethyl 2-(5-bromopyridin-2-yl)-2,2-difluoroacetate;ethyl (5-bromopyridin-2-yl)(difluoro)acetate
• CAS NO: 294181-95-6
• Molecular Formula: C₉H₈BrF₂NO₂
• Molecular Weight: 280.0661264
• Mol File: 294181-95-6.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 295.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.556±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.61±0.22(Predicted)
• CAS DataBase Reference: ethyl 2-(5-bromopyridin-2-yl)-2,2-difluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(5-bromopyridin-2-yl)-2,2-difluoroacetate(294181-95-6)
• EPA Substance Registry System: ethyl 2-(5-bromopyridin-2-yl)-2,2-difluoroacetate(294181-95-6)

Safety Data

• Hazardous Substances Data: 294181-95-6(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(5-bromopyridin-2-yl)-2,2-difluoroacetate is a chemical compound with the formula C9H8BrF2NO2. Ethyl 2-(5-bromopyridin-2-yl)-2,2-difluoroacetate is a difluoroacetate ester and contains a 5-bromopyridine moiety. It is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of complex organic molecules. Ethyl 2-(5-bromopyridin-2-yl)-2,2-difluoroacetate is a colorless liquid with a molecular weight of 263.07 g/mol. It is important to handle this chemical with caution, as it may have harmful effects if ingested, inhaled, or in contact with the skin or eyes.

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 667-27-6 Ethyl bromodifluoroacetate 
• 223463-13-6 2-iodo-5-bromopyridine 
• 205865-67-4 α-(trimethylsilyl)difluoroacetic acid ethyl ester 

Downstream Products

• 294182-06-2 2-(5-bromopyridin-2-yl)-1-(2,4-difluorophenyl)-2,2-difluoroethanone 
• 294182-28-8 5-bromo-2-((-2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridine 
• 1236001-15-2 2-(5-bromopyridin-2-yl)-2,2-difluoroethanol 
• 780769-39-3 2,2-difluoro-2-(5-methylpyridin-2-yl)ethanol 
• 1340593-86-3 2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-pyrazol-3-yl)-1-(5-(4-(trifluoromethoxy)phenyl)-pyridin-2-yl)propan-2-ol 
• 1340593-89-6 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-(4-fluorophenyl)pyridin-2-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol 
• 1340593-91-0 2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol 
• 1340593-95-4 2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)-1-(5-(4-(trifluoromethoxy)phenyl)pyridin-2-yl)propan-2-ol 
• 1340593-97-6 2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,3-triazol-1-yl)-1-(5-(4-(trifluoromethoxy)phenyl)pyridin-2-yl)propan-2-ol 
• 1340593-61-4 4-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)benzonitrile 
• 1357018-83-7 C₂₁H₁₂F₄N₂O 
• 1340593-62-5 2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(trifluoromethyl)phenyl)pyridin-2-yl)propan-2-ol 
• 1357018-82-6 C₂₁H₁₂F₇NO 
• 1340593-96-5 2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-(4-(trifluoromethoxy)phenyl)pyridine 

Relevant articles and documents

Synthetic method of aromatic ring group or aromatic heterocyclic tetrazole

The synthetic method comprises the following steps: (1) reacting 1.0 eq of ArI or HArI with 1.2 eq of ethyl 2, 2-difluoroacetate in the presence of DMSO as a solvent and 4.0 eq of Cu under the protection of nitrogen at 30 DEG C and 50 DEG C, and purifying to obtain a first intermediate compound; (2) dissolving 1.0 eq of the first intermediate compound in a mixed solvent of THF and water, adding 2.0 eq of LiOH, reacting at room temperature for 2 hours, spin-drying the solvent, adding HCl until the pH value is equal to 3, and filtering to obtain a second intermediate compound; and (3) reacting 1.0 eq of the second intermediate compound with 2.0 eq of diphenyl azide phosphate in the presence of 2.5 eq of triethylamine by taking tert-butyl alcohol as a solvent to generate aromatic ring group or aromatic heterocyclic tetrazole. The invention provides a novel synthetic method of aromatic ring group or aromatic heterocyclic tetrazole, wherein a target compound can be more conveniently obtained, and reagents participating in the reaction are low in toxicity, mild in reaction condition, simple and safe in aftertreatment, good in product quality and suitable for large-scale production.

1,4-THIAZINE DIOXIDE AND 1,2,4-THIADIAZINE DIOXIDE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present disclosure provides a class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, X, R2, R2', R3, R4, R5, R6, and R7 of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to Aβ plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.

ANTIFUNGAL COMPOUNDS AND PROCESSES FOR MAKING

Provided are polymorphic forms of compound 5 or 5*, or mixtures thereof, and polymorph forms of compound 14 or 14*, or mixtures thereof. Also provided are methods of preparing compound 5 or 5*, or mixtures thereof, and methods of preparing compound of 14 or 14*, or mixtures thereof, which are useful as antifungal agents. In particular, provided is new methodology for preparing polymorphs of the compounds described and substituted derivatives thereof.