29681-38-7

Basic information

• Product Name: 2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI)
• Synonyms: 2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI);5-Methylpyridine-2-carboxylic acid methyl ester;methyl 5-methylpicolinate;5-Methylpicolinic acid methyl ester;Methyl 5-methyl-2-pyridinecarboxylate;Methyl 5-methylpyridine-2-carboxylate;NSC 109152;2-Pyridinecarboxylic acid, 5-Methyl-, Methyl ester
• CAS NO: 29681-38-7
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.17
• Product Categories: CARBOXYLICESTER;GLYCINESCAFFOLD
• Mol File: 29681-38-7.mol
• Article Data: 19

Chemical Properties

• Melting Point: 54-55℃
• Boiling Point: 253℃
• Flash Point: 107℃
• Appearance: /
• Density: 1.104
• Vapor Pressure: 0.0182mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.98±0.10(Predicted)
• CAS DataBase Reference: 2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI)(29681-38-7)
• EPA Substance Registry System: 2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI)(29681-38-7)

Safety Data

• Hazardous Substances Data: 29681-38-7(Hazardous Substances Data)

Usage

General Description

2-Pyridinecarboxylic acid, 5-methyl-, methyl ester (9CI) is a chemical compound with the molecular formula C8H9NO2. It is a methyl ester derivative of 5-methyl-2-pyridinecarboxylic acid and is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI) is known for its diverse range of biological activities, including its role as an inhibitor of the enzyme dihydrofolate reductase, which is involved in the synthesis of DNA and RNA. Additionally, 2-Pyridinecarboxylic acid, 5-methyl-, methyl ester (9CI) has been studied for its potential antioxidant and anticancer properties. Overall, this chemical compound has significant potential for applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C8H9NO2/c1-6-3-4-7(9-5-6)8(10)11-2/h3-5H,1-2H3

Upstream product

• 67-56-1 methanol 
• 2459-07-6 methyl pyridine-2-carboxylate 
• 186581-53-3 diazomethane 
• 4434-13-3 2-carboxy-5-methylpyridine 
• 768368-54-3 Toluene-4-sulfonic acid 3,9,9-trimethyl-7,11-dioxo-8,10-dioxa-1-aza-spiro[5.5]undec-3-en-1-yl ester 
• 589-93-5 2,5-dimethylpyridine 
• 3510-66-5 2-Bromo-5-methylpyridine 
• 201230-82-2 carbon monoxide 
• 18368-64-4 2-chloro-5-methylpyridine 
• 452-86-8 4-methyl-1,2-dihydroxybenzene 
• 124-38-9 carbon dioxide 
• 13737-09-2 5-methyl-2-(trimethylsilyl)pyridine 
• 74-88-4 methyl iodide 

Downstream Products

• 401792-77-6 methyl 5-methyl-2-pyridinecarboxylate N-oxide 
• 401792-80-1 methyl 6-hydroxy-5-methyl-2-pyridinecarboxylate 
• 401792-82-3 methyl 6-methoxy-5-methyl-2-pyridinecarboxylate 
• 401792-87-8 methyl 5-formyl-6-methoxy-2-pyridinecarboxylate 
• 401792-84-5 methyl 5-(bromomethyl)-6-methoxy-2-pyridinecarboxylate 
• 401792-93-6 (+)-methyl N-(benzyloxycarbonyl)-3-[2-(methoxycarbonyl)-6-methoxy-5-pyridinyl]-L-alaninate 
• 478946-91-7 5-((S)-2-Benzyloxycarbonylamino-2-carboxy-ethyl)-6-methoxy-pyridine-2-carboxylic acid 
• 55876-84-1 methyl 5-(bromomethyl)pyridine-2-carboxylate 
• 446880-80-4 2-(2-bromopyridin-4-yl)-1-(6-methylpyridin-2-yl)ethan-1-one 
• 1369491-73-5 C₁₀H₁₄NO₄P 
• 1382991-46-9 methyl 5-(3-fluorobenzyl)picolinate 
• 1382991-47-0 5-(3-fluorobenzyl)picolinic acid 
• 1417421-44-3 methyl 5-((3-ethylphenoxy)methyl)picolinate 
• 1417421-45-4 5-((3-ethylphenoxy)methyl)picolinic acid 

Relevant articles and documents

Asymmetric synthesis of (S)-(-)-acromelobinic acid

A total synthesis of (S)-(-)-acromelobinic acid 2, which was isolated from clitocybe acromelalga, was achieved via an asymmetric hydrogenation protocol. Dehydroamino acid derivative 12 was prepared from 2,5-lutidine 5 and subjected to asymmetric hydrogenation using (S,S)-[Rh(Et-DuPHOS)(COD)]BF4 to give the (S)-(+)-pyridylalanine derivative 13 in 93% yield and >96% e.e. Removal of the protecting groups in (S)-(+)-13 afforded (S)-(-)-acromelobinic acid 2.

SUBSTITUTED BENZOXAZOLES

The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.

CO2 Conversion into Esters by Fluoride-Mediated Carboxylation of Organosilanes and Halide Derivatives

A one-step conversion of CO2 into heteroaromatic esters is presented under metal-free conditions. Using fluoride anions as promoters for the C-Si bond activation, pyridyl, furanyl, and thienyl organosilanes are successfully carboxylated with CO2 in the presence of an electrophile. The mechanism of this unprecedented reaction has been elucidated based on experimental and computational results, which show a unique catalytic influence of CO2 in the C-Si bond activation of pyridylsilanes. The methodology is applied to 18 different esters, and it has enabled the incorporation of CO2 into a polyester material for the first time. Metal free! A novel methodology is described to convert CO2 into heteroaromatic esters in the presence of organosilanes and organic halides using fluoride anions as promoters for the C-Si bond activation (see scheme). CO2 exhibits a unique catalytic influence in the C-Si bond cleavage of pyridylsilanes, serving as a traceless activator.