301174-66-3

Basic information

• Product Name: 4(5H)-Thiazolone, 2-amino-5-[(4-fluorophenyl)methyl]-
• CAS NO: 301174-66-3
• Molecular Formula: C10H9FN2OS
• Molecular Weight: 224.259
• Mol File: 301174-66-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4(5H)-Thiazolone, 2-amino-5-[(4-fluorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(5H)-Thiazolone, 2-amino-5-[(4-fluorophenyl)methyl]-(301174-66-3)
• EPA Substance Registry System: 4(5H)-Thiazolone, 2-amino-5-[(4-fluorophenyl)methyl]-(301174-66-3)

Safety Data

• Hazardous Substances Data: 301174-66-3(Hazardous Substances Data)

Upstream product

• 371-40-4 4-fluoroaniline 
• 17356-08-0 thiourea 
• 82455-06-9 methyl 2-bromo-3-(4-fluorophenyl)propionate 

Downstream Products

• 291536-42-0 5-(4-fluorophenylmethyl)-2,4-thiazolidinedione 

Relevant articles and documents

Structural characterization of impurities in pioglitazone

In the pioglitazone bulk drug three prominent impurities I-III were detected up to concentrations of 0.1% (ranging from 0.05-0.1%) by reversed phase HPLC. These impurities were isolated from enriched mother liquor samples and characterized as 5-(4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione (I) 5-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione (II), 2-[2-(4-bromophenoxy) ethyl-5-ethyl pyridine (III) based on their 1H, and 13C NMR, DEPT, Mass and IR spectral data. Structure elucidation and synthesis of these impurities is discussed.