3020-06-2Relevant articles and documents
Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding
Lee, Jeewoo,Kim, Su Yeon,Park, Soyoung,Lim, Ju-Ok,Kim, Ji-Min,Kang, Myungshim,Lee, Jiyoun,Kang, Sang-Uk,Choi, Hyun-Kyung,Jin, Mi-Kyung,Welter, Jacqueline D.,Szabo, Tamas,Tran, Richard,Pearce, Larry V.,Toth, Attila,Blumberg, Peter M.
, p. 1055 - 1069 (2007/10/03)
We previously described a series of N-(3-acyloxy-2-benzylpropyl) homovanillate and N′-(4-hydroxy-3-methoxybenzyl) thiourea derivatives that were potent VR1 agonists with high-affinities and excellent analgesic profiles. The design of these simplified RTX analogues was based on our RTX-derived pharmacophore model which incorporates the 4-hydroxy-3- methoxyphenyl (A-region), C20-ester (B-region), orthophenyl (C1-region) and C3-keto (C2-region) groups of RTX. For the purpose of optimizing the spatial arrangement of the four principal pharmacophores on the lead agonists (1-4), we have modified the distances in the parent C-region, 3-acyloxy-2-benzylpropyl groups, by lengthening or shortening one carbon to vary the distances between the pharmacophores. We find that two of the amides, 4 and 19, possess EC50 values i) and calcium influx (EC50) values. The binding affinities of the agonists correlated best with the RMS values derived from RTX conformation E (r2=0.92), predicting a model of the active conformation of RTX and related vanilloids for binding to VR1. Poorer correlation was obtained between any of the conformations and the EC 50 values for calcium influx.
188. Addition of Carbon Nucleophiles to Tricarbonylchromium Complexes of 1,2-Dihydrocyclobutabenzene, Indane, 1,2,3,4-Tetrahydronaphthalene and ortho-Xylene
Kuendig, E. Peter,Grivet, Chantal,Wenger, Eric,Bernardinelli, Gerald,Williams, Alan F.
, p. 2009 - 2023 (2007/10/02)
3-Substituted 1,2-dihydrocyclobutabenzenes (bicycloocta-1,3,5-triene) are readily accessible from (1) via a two-step sequence which involves addition of a nucleophile and oxidation of the intermediate anionic