318-54-7Relevant articles and documents
Acylation of activated aromatic substrates under mild conditions with (RCO)2O/Me2S/BF3
Kiselyov, Alexander S.
, p. 4005 - 4008 (1995)
An efficient procedure for acylation and perfluoroacylation of activated aromatic substrates under mild conditions using the system (RCO)2O/Me2S/BF3 in CH2Cl2 is described. It is believed that dimethylacylsulfonium salts, RCOSMe2+RCO2BF3-, are the active acylating agents.
Salicylaldehyde-Promoted Cobalt-Catalyzed C-H/N-H Annulation of Indolyl Amides with Alkynes: Direct Synthesis of a 5-HT3 Receptor Antagonist Analogue
Huang, Mao-Gui,Shi, Shuai,Li, Ming,Liu, Yue-Jin,Liu, Yue-Jin
, p. 7094 - 7099 (2021/09/14)
A cobalt-catalyzed annulation of the C(sp2)-H/N-H bond of indoloamides with alkynes assisted by 8-aminoquinoline is reported for the synthesis of six-membered indololactams. The use of salicylaldehyde as the ligand is crucial for this transformation. The protocol has a broad scope for both alkynes and indoles. Preparing an active Co complex illustrates that salicylaldehyde plays a key role in the C-H activation step. The synthetic applications are proven by the gram-scale reaction and one-step construction of the multicyclic 5-HT3 receptor antagonist.
Cell death inhibitor and novel compound
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Paragraph 0187-0190; 0193; 0196; 0236-0237; 0240; 0247, (2018/03/13)
Provided is a cell-death inhibitor including, as an active ingredient thereof, a compound represented by formula (1), and/or a compound represented by formula (2). The cell-death inhibitor exhibits high cell-death inhibition activity.
Synthesis method for 3-(trifluoroacetyl)indole derivative
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Paragraph 0010, (2017/08/31)
The invention discloses a synthesis method for a 3-(trifluoroacetyl)indole derivative and belongs to the technical field of organic synthesis intermediates. The method particularly includes the following steps: 1) feeding dimethyl sulfoxide, an indole derivative, ethyl trifluoropyruvate and cuprous chloride into a pressure-resistant reaction tube, tightly screwing a plug of the reaction tube, and performing a magnetic-stirring reaction for 12 h in oil bath at 80 DEG C; 2) when the reaction is finished, performing extraction with ethyl ether and mixing organic phases, performing pressure reduced evaporation to remove most of the solvent, and performing column chromatography separation and purification to residual mixture liquid with petroleum ether and ethyl acetate, volume ratio being 5:1-10:1, as a leaching liquid, thereby producing the product. The 3-(trifluoroacetyl)indole derivative has wide applications in the fields such as medicines, pesticides, etc. The synthesis method is low in cost, has simple operations and high yield, and has excellent application prospect.